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Comparison of risk factors and clinical responses to proton pump inhibitors in patients with erosive oesophagitis and non-erosive reflux disease
DC Field | Value | Language |
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dc.contributor.author | Lee, E. S. | - |
dc.contributor.author | Kim, N. | - |
dc.contributor.author | Lee, S. H. | - |
dc.contributor.author | Park, Y. S. | - |
dc.contributor.author | Jeong, S. H. | - |
dc.contributor.author | Jung, H. C. | - |
dc.contributor.author | Song, I. S. | - |
dc.contributor.author | Lee, D. H. | - |
dc.contributor.author | Kim, J. W. | - |
dc.date.accessioned | 2012-05-24T05:39:21Z | - |
dc.date.available | 2012-05-24T05:39:21Z | - |
dc.date.issued | 2009-07-15 | - |
dc.identifier.citation | ALIMENTARY PHARMACOLOGY & THERAPEUTICS; Vol.30 2; 154-164 | ko_KR |
dc.identifier.issn | 0269-2813 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76410 | - |
dc.description.abstract | P>Background There has been no report on the response to proton pump inhibitor (PPI) therapy and on-demand or the relapse rate of non-erosive reflux disease (NERD) and erosive oesophagitis in Korea. Aim To compare the risk factors, clinical symptoms and PPI responses between patients with erosive oesophagitis and NERD patients. Methods A survey was performed prospectively in the erosive oesophagitis (205 patients) and NERD group (200 patients). Clinical symptoms, risk factors and PPI responses were analysed. On-demand therapy and the relapse rate of GERD symptoms were investigated during a one-year follow-up. Results BMI >= 25 (OR 3.0, 95% CI 1.1-8.3), alcohol use (OR 2.9, 95% CI 1.0-8.3), hiatal hernia (OR 5.0, 95% CI 1.2-20) and triglyceride >= 150 mg/dL (OR 4.0, 95% CI 1.7-10) were more common in the erosive oesophagitis group than in the NERD group by multivariate analysis. The ratio of oesophageal to extra-oesophageal symptoms was higher in the erosive oesophagitis group compared with the NERD group (P < 0.001). The PPI response rates at 8 weeks were different (P = 0.02); refractory rates were higher in the NERD group (16.7%) compared with the erosive oesophagitis group (6.0%). However, there was no significant difference between the two groups in on-demand therapy or the relapse rate. Conclusion These results suggest that the underlying pathogenic mechanisms of erosive oesophagitis and NERD are distinct. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.title | Comparison of risk factors and clinical responses to proton pump inhibitors in patients with erosive oesophagitis and non-erosive reflux disease | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1111/j.1365-2036.2009.04021.x | - |
dc.citation.journaltitle | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | - |
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dc.description.tc | 7 | - |
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