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ATP Measurement Predicts Porcine Islet Transplantation Outcome in Nude Mice

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dc.contributor.authorKim, Jae Hyeon-
dc.contributor.authorPark, Sang Gyu-
dc.contributor.authorLee, Han Na-
dc.contributor.authorLee, Yeon Yi-
dc.contributor.authorKim, Hyong-Il-
dc.contributor.authorKim, Sun Hee-
dc.contributor.authorHa, Jongwon-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorKim, Sang Jun-
dc.contributor.authorPark, Chung-Gyu-
dc.contributor.authorYu, Jae Eun-
dc.contributor.authorPark, Ho Sun-
dc.date.accessioned2012-05-25T01:46:23Z-
dc.date.available2012-05-25T01:46:23Z-
dc.date.issued2009-01-27-
dc.identifier.citationTRANSPLANTATION; Vol.87 2; 166-169ko_KR
dc.identifier.issn0041-1337-
dc.identifier.urihttps://hdl.handle.net/10371/76450-
dc.description.abstractCurrent nude mice islet transplantation studies cannot be used prospectively. Therefore, to predict transplantation outcomes, reliable and rapid assays for islet quality assessment are warranted. This study evaluated the predictive power of the porcine islet ATP content on the outcomes of islet transplantation in nude mice. Here, we report that the ATP measurement using a small number of handpicked islets with a diameter of 100 to 150 gm is a good predictor of islet graft efficacy in nude mice. Using receiver-operator characteristic analysis, the area under the curve of the ATP content using a small number of handpicked islets was 0.867 (95% confidence interval 0.744-0.989, P<0.001). The sensitivity and the specificity measured were 83.3% and 73.3%, respectively. In conclusion, a simple and a rapid measurement of intraislet ATP content could be a promising substitute for current nude mice islet transplantation studies.ko_KR
dc.description.sponsorshipThis work was supported by a grant from the Innovative Research Institute
for Cell Therapy, Republic of Korea (project no A062260) (J.H.K., S.G.P.,
H.S.P., and K.S.P.) and the Korea Health 21 R&D Project, Ministry of
Health and Welfare, Republic of Korea (project no. A040004) (J.H.K.,
H.K., J.E.Y., S.H.K., and K.S.P.).
ko_KR
dc.language.isoenko_KR
dc.publisherLIPPINCOTT WILLIAMS & WILKINSko_KR
dc.subjectATP contentko_KR
dc.subjectDiabetic miceko_KR
dc.subjectIslet qualityko_KR
dc.subjectIslet assessmentko_KR
dc.titleATP Measurement Predicts Porcine Islet Transplantation Outcome in Nude Miceko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김재현-
dc.contributor.AlternativeAuthor박상규-
dc.contributor.AlternativeAuthor이한나-
dc.contributor.AlternativeAuthor이연이-
dc.contributor.AlternativeAuthor박호선-
dc.contributor.AlternativeAuthor김형일-
dc.contributor.AlternativeAuthor유재은-
dc.contributor.AlternativeAuthor김선희-
dc.contributor.AlternativeAuthor박정규-
dc.contributor.AlternativeAuthor하종원-
dc.contributor.AlternativeAuthor김상준-
dc.contributor.AlternativeAuthor박경수-
dc.identifier.doi10.1097/TP.0b013e318191e925-
dc.citation.journaltitleTRANSPLANTATION-
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dc.description.tc10-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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