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The prognostic factors of systemic sclerosis for survival among Koreans

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dc.contributor.authorKim, Jinhyun-
dc.contributor.authorPark, Sue Kyung-
dc.contributor.authorMoon, Ki Won-
dc.contributor.authorLee, Eun Young-
dc.contributor.authorSong, Yeong Wook-
dc.contributor.authorLee, Eun Bong-
dc.contributor.authorLee, Yun Jong-
dc.date.accessioned2012-05-29T02:18:08Z-
dc.date.available2012-05-29T02:18:08Z-
dc.date.issued2010-03-
dc.identifier.citationCLINICAL RHEUMATOLOGY; Vol.29 3; 297-302ko_KR
dc.identifier.issn0770-3198-
dc.identifier.urihttps://hdl.handle.net/10371/76520-
dc.description.abstractSystemic sclerosis (SSc) is a systemic autoimmune disease characterized by fibrosis of the skin and internal organs, which can cause significant morbidity and mortality. The prognostic factors for survival were not fully evaluated in Asian population. We investigated the prognostic factors for survival of SSc among Korean patients. A total of 243 SSc patients were enrolled from Seoul National University Hospital between 1972 and 2007. Age at onset, gender, cutaneous subset, autoantibody status, major organ involvement, and occurrence of malignancy were evaluated with all-cause mortality as the end point. A multivariate Cox proportional hazard model was used to retrieve the prognostic factors for survival. During the follow-up of 1,967 person-years, 33 patients died. Old age at onset (hazard ratio [HR] 7.4, 95% confidence interval [95% CI] 1.9-28.1), diffuse cutaneous subset (HR 2.5, 95% CI 1.1-5.9), presence of anti-Scl-70 antibody (HR 3.0, 95% CI 1.2-7.1), forced vital capacity less than 70% (HR 2.8, 95% CI 1.3-6.2), and heart involvement (HR 4.2, 95% CI 1.7-10.2) were found to be significant risk factors for mortality in multivariate analysis. In Korean SSc patients, old age, diffuse cutaneous involvement, anti-Scl-70 antibody, and internal organ involvement are risk factors for mortality.ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGERko_KR
dc.subjectKoreanko_KR
dc.subjectPrognostic factorsko_KR
dc.subjectSurvivalko_KR
dc.subjectSystemic sclerosisko_KR
dc.titleThe prognostic factors of systemic sclerosis for survival among Koreansko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김진현-
dc.contributor.AlternativeAuthor박수경-
dc.contributor.AlternativeAuthor문기원-
dc.contributor.AlternativeAuthor이은영-
dc.contributor.AlternativeAuthor이윤종-
dc.contributor.AlternativeAuthor송영욱-
dc.contributor.AlternativeAuthor이은봉-
dc.identifier.doi10.1007/s10067-009-1324-7-
dc.citation.journaltitleCLINICAL RHEUMATOLOGY-
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dc.description.tc1-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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