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Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Lee, Jin Young | - |
dc.contributor.author | Sim, Young-Suk | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.contributor.author | Kang, Ju Seop | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Kim, Sunil | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Youn, Jeehee | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Kim, Young-Jeon | - |
dc.date.accessioned | 2012-05-29T02:22:51Z | - |
dc.date.available | 2012-05-29T02:22:51Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF IMMUNOLOGY; Vol.40 6; 1651-1662 | ko_KR |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76521 | - |
dc.description.abstract | Although Helicobacter pylori infections of the gastric mucosa are characterized by the infiltration of inflammatory cells such as eosinophils, the responses of eosinophils to H. pylori vacuolating cytotoxin (VacA) have not been fully elucidated. This study investigates the role of VacA in the apoptosis of human eosinophils. We treated human eosinophils with purified H. pylori VacA and observed that induction of apoptosis is a relatively late event. Expression of cellular inhibitor of apoptosis protein (c-IAP)-2 was upregulated during the early period of VacA stimulation, and transfection with c-IAP2 siRNA augmented apoptotic cell death. VacA caused the translocation of cytoplasmic Bax to the mitochondria and increased cytochrome c release from mitochondria in eosinophils. Transfection of an EoL-1 eosinophil cell line with Bax siRNA decreased the release of cytochrome c and DNA fragmentation. Furthermore, apoptosis facilitated by Bax and cytochrome c was primarily regulated by p38 MAPK in VacA-treated eosinophils. These results suggest that the exposure of human eosinophils to H. pylori VacA induces the early upregulation of c-IAP2 and a relatively late apoptotic response, with the apoptosis progressing through a sequential pathway that includes p38 MAPK activation, Bax translocation, and cytochrome c release. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-V C H VERLAG GMBH | ko_KR |
dc.subject | Apoptosis | ko_KR |
dc.subject | H. pylori vacuolating cytotoxin | ko_KR |
dc.subject | Eosinophils | ko_KR |
dc.title | Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김정목 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 이진영 | - |
dc.contributor.AlternativeAuthor | 심영숙 | - |
dc.contributor.AlternativeAuthor | 김영전 | - |
dc.contributor.AlternativeAuthor | 오유경 | - |
dc.contributor.AlternativeAuthor | 윤호주 | - |
dc.contributor.AlternativeAuthor | 강주섭 | - |
dc.contributor.AlternativeAuthor | 윤지희 | - |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 김선일 | - |
dc.identifier.doi | 10.1002/eji.200939882 | - |
dc.citation.journaltitle | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.description.citedreference | Franchi L, 2009, NAT IMMUNOL, V10, P241, DOI 10.1038/ni.1703 | - |
dc.description.citedreference | Shen ZJ, 2009, NAT IMMUNOL, V10, P257, DOI 10.1038/ni.1697 | - |
dc.description.citedreference | Bergsbaken T, 2009, NAT REV MICROBIOL, V7, P99, DOI 10.1038/nrmicro2070 | - |
dc.description.citedreference | Lee JY, 2009, J MOL MED-JMM, V87, P169, DOI 10.1007/s00109-008-0415-2 | - |
dc.description.citedreference | Friboulet L, 2008, NEOPLASIA, V10, P1183, DOI 10.1593/neo.08590 | - |
dc.description.citedreference | Piazuelo MB, 2008, HUM PATHOL, V39, P1360, DOI 10.1016/j.humpath.2008.01.012 | - |
dc.description.citedreference | Kim JM, 2008, EUR J IMMUNOL, V38, P2190, DOI 10.1002/eji.200838191 | - |
dc.description.citedreference | Wong WWL, 2008, IUBMB LIFE, V60, P390, DOI 10.1002/iub.51 | - |
dc.description.citedreference | Hogan SP, 2008, CLIN EXP ALLERGY, V38, P709, DOI 10.1111/j.1365-2222.2008.02958.x | - |
dc.description.citedreference | Kim JM, 2008, LAB INVEST, V88, P541, DOI 10.1038/labinvest.2008.16 | - |
dc.description.citedreference | KNUDSON CM, 2008, METH MOL B, V414, P95 | - |
dc.description.citedreference | Mueller S, 2008, BEST PRACT RES CL GA, V22, P425, DOI 10.1016/j.bpg.2007.12.008 | - |
dc.description.citedreference | Lee JY, 2007, J MOL MED-JMM, V85, P1393, DOI 10.1007/s00109-007-0237-7 | - |
dc.description.citedreference | Sheng G, 2007, AM J PHYSIOL-GASTR L, V293, pG599, DOI 10.1152/ajpgi.00182.2007 | - |
dc.description.citedreference | Wilson KT, 2007, GASTROENTEROLOGY, V133, P288, DOI 10.1053/j.gastro.2007.05.008 | - |
dc.description.citedreference | Kim JM, 2007, INFECT IMMUN, V75, P3373, DOI 10.1128/IAI.01940-06 | - |
dc.description.citedreference | Gomez-Lazaro M, 2007, MOL PHARMACOL, V71, P736, DOI 10.1124/mol.106.030718 | - |
dc.description.citedreference | Kempkensteffen C, 2007, INT J CANCER, V120, P1081, DOI 10.1002/ijc.22416 | - |
dc.description.citedreference | Antignani A, 2006, CURR OPIN CELL BIOL, V18, P685, DOI 10.1016/j.ceb.2006.10.004 | - |
dc.description.citedreference | Er E, 2006, BBA-BIOENERGETICS, V1757, P1301, DOI 10.1016/j.bbabio.2006.05.032 | - |
dc.description.citedreference | Kim JM, 2006, EUR J IMMUNOL, V36, P2446, DOI 10.1002/eji.200535808 | - |
dc.description.citedreference | Kusters JG, 2006, CLIN MICROBIOL REV, V19, P449, DOI 10.1128/CMR.00054-05 | - |
dc.description.citedreference | Yamasaki E, 2006, J BIOL CHEM, V281, P11250, DOI 10.1074/jbc.M509404200 | - |
dc.description.citedreference | Lu H, 2005, CURR OPIN GASTROEN, V21, P653 | - |
dc.description.citedreference | Gauthier NC, 2005, MOL BIOL CELL, V16, P4852, DOI 10.1091/mbc.E05-05-0398 | - |
dc.description.citedreference | Li DWC, 2005, MOL BIOL CELL, V16, P4437, DOI 10.1091/mbc.E05-01-0010 | - |
dc.description.citedreference | Vaux DL, 2005, CELL DEATH DIFFER, V12, P1205, DOI 10.1038/sj.cdd.4401696 | - |
dc.description.citedreference | Kim JM, 2005, EUR J IMMUNOL, V35, P2648, DOI 10.1002/eji.200526321 | - |
dc.description.citedreference | Nakayama M, 2004, J BIOL CHEM, V279, P7024, DOI 10.1074/jbc.M308898200 | - |
dc.description.citedreference | VAN LA, 2004, FASEB J, V18, P1946 | - |
dc.description.citedreference | Adams JM, 2003, GENE DEV, V17, P2481, DOI 10.1101/gad.1126903 | - |
dc.description.citedreference | Nishihara H, 2003, P NATL ACAD SCI USA, V100, P8921, DOI 10.1073/pnas.1533221100 | - |
dc.description.citedreference | Yang YL, 2003, FASEB J, V17, P790 | - |
dc.description.citedreference | KIM JM, 2003, AM J PHYSIOL-GASTR L, V285, P1171 | - |
dc.description.citedreference | Brito GAC, 2002, J INFECT DIS, V186, P1438 | - |
dc.description.citedreference | Kalia N, 2002, GUT, V51, P641 | - |
dc.description.citedreference | Salvesen GS, 2002, NAT REV MOL CELL BIO, V3, P401, DOI 10.1038/nrm830 | - |
dc.description.citedreference | Dewson G, 2001, BLOOD, V98, P2239 | - |
dc.description.citedreference | Kim JM, 2001, CLIN EXP IMMUNOL, V123, P421 | - |
dc.description.citedreference | Gao LY, 2000, TRENDS MICROBIOL, V8, P306, DOI 10.1016/S0966-842X(00)01784-4 | - |
dc.description.citedreference | Erjefalt JS, 2000, AM J RESP CRIT CARE, V161, P2074 | - |
dc.description.citedreference | Tepes B, 1999, J PATHOL, V188, P24 | - |
dc.description.citedreference | Kim JM, 1998, J CLIN INVEST, V102, P1815 | - |
dc.description.citedreference | Kodama K, 1998, J GASTROENTEROL, V33, P14 | - |
dc.description.citedreference | Rudi J, 1998, J CLIN MICROBIOL, V36, P944 | - |
dc.description.citedreference | Gon S, 1997, J LEUKOCYTE BIOL, V62, P309 | - |
dc.description.citedreference | Kroemer G, 1997, NAT MED, V3, P614 | - |
dc.description.citedreference | Hatz RA, 1996, SCAND J GASTROENTERO, V31, P222 | - |
dc.description.citedreference | DEBERNARD M, 1995, J BIOL CHEM, V270, P23937 | - |
dc.description.citedreference | GENTA RM, 1993, MODERN PATHOL, V6, P281 | - |
dc.description.citedreference | MCGOVERN TW, 1991, DIGEST DIS SCI, V36, P435 | - |
dc.description.tc | 3 | - |
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