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Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus

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dc.contributor.authorPark, Sang Gyu-
dc.contributor.authorPark, Ho Seon-
dc.contributor.authorJeong, In-Kyong-
dc.contributor.authorCho, Young Min-
dc.contributor.authorKang, Young-Sun-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorKim, Sunghoon-
dc.contributor.authorLee, Hong Kyu-
dc.date.accessioned2012-05-29T04:19:13Z-
dc.date.available2012-05-29T04:19:13Z-
dc.date.issued2010-06-
dc.identifier.citationBIOMARKERS; Vol.15 4; 358-366ko_KR
dc.identifier.issn1354-750X-
dc.identifier.urihttps://hdl.handle.net/10371/76528-
dc.description.abstractObjectives: To investigate whether or not antiaminoacyl-tRNA synthetase (aaRS) autoantibodies could be detected in patients with type 1 diabetes mellitus (DM) and be used as a diagnostic marker for type 1 DM, autoantibodies against aaRSs were measured in the plasma of normal subjects, patients with type 1 DM and patients with type 2 DM. Methods: An enzyme-linked immunosorbent assay was performed to detect anti-aaRS autoantibodies in the plasma of normal subjects, and patients with type 1 DM, and patients with type 2 DM. Results: From the 65 (normal), 58 (type 1 DM) and 57 (type 2 DM) subjects, anti-aaRS autoantibodies were found in 37.9% of patients with type 1 DM compared with 1.54% of the non-diabetic controls, and 5.26% of the patients with type 2 DM (p<0.0001). In addition, anti-aaRS autoantibodies were identified in 30% of patients with type 1 DM without classical type 1 DM autoantibodies. Conclusion: Anti-aaRS autoantibodies were identified in 37.9% of patients with type 1 DM. The results of this study demonstrate for the first time that autoantibodies against aaRSs are specifically associated with type 1 DM.ko_KR
dc.language.isoenko_KR
dc.publisherINFORMA HEALTHCAREko_KR
dc.subjectPancreasko_KR
dc.subjectautoantibodyko_KR
dc.subjectantisynthetase syndromeko_KR
dc.subjectELISAko_KR
dc.subjectautoimmune diseaseko_KR
dc.titleAutoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitusko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박상규-
dc.contributor.AlternativeAuthor박호선-
dc.contributor.AlternativeAuthor정인경-
dc.contributor.AlternativeAuthor조영민-
dc.contributor.AlternativeAuthor이홍규-
dc.contributor.AlternativeAuthor강영선-
dc.contributor.AlternativeAuthor김성훈-
dc.contributor.AlternativeAuthor박경수-
dc.identifier.doi10.3109/13547501003777823-
dc.citation.journaltitleBIOMARKERS-
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