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Hepatitis A: Clinical Manifestations and Management

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dc.contributor.authorJeong, Sook-Hyang-
dc.contributor.authorLee, Hyo-Suk-
dc.date.accessioned2012-05-29T06:20:33Z-
dc.date.available2012-05-29T06:20:33Z-
dc.date.issued2010-
dc.identifier.citationINTERVIROLOGY; Vol.53 1; 15-19ko_KR
dc.identifier.issn0300-5526-
dc.identifier.urihttps://hdl.handle.net/10371/76549-
dc.description.abstractDue to improved living conditions and subsequent changes in hepatitis A epidemiology, the disease burden of hepatitis A is increasing in many regions. Recently, Korea has faced a large, community-wide outbreak of hepatitis A, which has prompted a vaccination program. The clinical spectrum of hepatitis A virus infection ranges from asymptomatic infection to fulminant hepatitis. Clinical manifestations depend on the age of the host: less than 30% of infected young children are symptomatic, while about 80% of infected adults manifest severe hepatitis with remarkably elevated serum aminotransferases. Fulminant hepatitis is rare, with a reported incidence from 0.015 to 0.5%. Atypical manifestations include relapsing hepatitis and prolonged cholestasis, and complicated cases with acute kidney injury have been reported. Extrahepatic manifestations, such as autoimmune hemolytic anemia, aplastic anemia, pure red cell aplasia, pleural or pericardial effusion, acute reactive arthritis, acute pancreatitis, acalculous cholecystitis, mononeuritis, and Guillain-Barre syndrome, have been rarely reported. Management of hepatitis A includes general supportive care, and critical decisions regarding liver transplantation await further studies on prognostic predictors. Fundamental management of hepatitis A is active vaccination. However, a vaccination program should be adapted to the regional situation, according to differing epidemiology and disease burden. Copyright (C) 2010 S. Karger AG, Baselko_KR
dc.language.isoenko_KR
dc.publisherKARGERko_KR
dc.subjectClinical manifestationko_KR
dc.subjectPrognosisko_KR
dc.subjectManagementko_KR
dc.subjectHepatitis A virusko_KR
dc.subjectKoreako_KR
dc.titleHepatitis A: Clinical Manifestations and Managementko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor정숙향-
dc.contributor.AlternativeAuthor이효석-
dc.identifier.doi10.1159/000252779-
dc.citation.journaltitleINTERVIROLOGY-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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