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Visceral Obesity and Insulin Resistance as Risk Factors for Colorectal Adenoma: A Cross-Sectional, Case-Control Study
DC Field | Value | Language |
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dc.contributor.author | Kang, Hyoun Woo | - |
dc.contributor.author | Kim, Donghee | - |
dc.contributor.author | Kim, Hwa Jung | - |
dc.contributor.author | Kim, Chung Hyeon | - |
dc.contributor.author | Park, Min Jung | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.contributor.author | Sung, Myung-Whun | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Kim, Young Sun | - |
dc.date.accessioned | 2012-05-29T06:47:25Z | - |
dc.date.available | 2012-05-29T06:47:25Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | AMERICAN JOURNAL OF GASTROENTEROLOGY; Vol.105 1; 178-187 | ko_KR |
dc.identifier.issn | 0002-9270 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76558 | - |
dc.description.abstract | OBJECTIVES: Colorectal adenoma is known to be associated with obesity, but the association between colorectal adenoma and visceral adipose tissue (VAT) area measured by abdominal computed tomography (CT) has not been documented clearly. In addition, the relationship between insulin resistance and colorectal adenomas, which underlies the mechanism that links obesity and colorectal adenoma, has not been studied extensively. The aim of this study was to examine VAT area and insulin resistance as risk factors of colorectal adenoma. METHODS: A cross-sectional, case-control study was conducted in Koreans that presented for health check-ups. Subjects underwent various laboratory tests, abdominal CT, and colonoscopy. VAT, subcutaneous adipose tissue (SAT), and homeostatic metabolic assessment (HOMA) index were evaluated as potential risk factors of colorectal adenoma in 2,244 age- and sex-matched subjects. RESULTS: According to univariate analysis, the prevalences of smoking, hypertension, metabolic syndrome, and family history of colorectal cancer were higher in the adenoma group than in the normal control group. In addition, body mass index, waist circumference, triglyceride, high-density lipoprotein cholesterol, and VAT and SAT areas were significantly different in the two groups. According to the multivariate analysis adjusted for multiple confounders, VAT area was independently associated with the risk of colorectal adenoma (odds ratio (OR) = 3.09, 95 % confidence interval (CI): 2.19-4.36, highest quintile vs. lowest quintile). Mean HOMA index was higher in the adenoma group than in the control group (OR = 1.99, 95 % CI: 1.35-2.92, highest vs. lowest quintile). CONCLUSIONS: Visceral obesity was found to be an independent risk factor of colorectal adenoma, and insulin resistance was associated with the presence of colorectal adenoma. Am J Gastroenterol 2010; 105: 178-187; doi:10.1038/ajg.2009.541; published online 15 September 2009 | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | NATURE PUBLISHING GROUP | ko_KR |
dc.title | Visceral Obesity and Insulin Resistance as Risk Factors for Colorectal Adenoma: A Cross-Sectional, Case-Control Study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 강현우 | - |
dc.contributor.AlternativeAuthor | 김동희 | - |
dc.contributor.AlternativeAuthor | 김화정 | - |
dc.contributor.AlternativeAuthor | 김정현 | - |
dc.contributor.AlternativeAuthor | 김영순 | - |
dc.contributor.AlternativeAuthor | 박민정 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 조상헌 | - |
dc.contributor.AlternativeAuthor | 성명훈 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.identifier.doi | 10.1038/ajg.2009.541 | - |
dc.citation.journaltitle | AMERICAN JOURNAL OF GASTROENTEROLOGY | - |
dc.description.citedreference | Chung SJ, 2008, GUT, V57, P1360, DOI 10.1136/gut.2007.147090 | - |
dc.description.citedreference | Millan MS, 2008, DIS COLON RECTUM, V51, P1217, DOI 10.1007/s10350-008-9315-3 | - |
dc.description.citedreference | Oh TH, 2008, J GASTROEN HEPATOL, V23, P411, DOI 10.1111/j.1440-1746.2007.05125.x | - |
dc.description.citedreference | Moghaddam AA, 2007, CANCER EPIDEM BIOMAR, V16, P2533, DOI 10.1158/1055-9965.EPI-07-0708 | - |
dc.description.citedreference | Giovannucci E, 2007, AM J CLIN NUTR, V86, p836S | - |
dc.description.citedreference | Kim JH, 2007, CANCER EPIDEM BIOMAR, V16, P1543, DOI 10.1158/1055-9965 | - |
dc.description.citedreference | Byeon JS, 2007, GASTROINTEST ENDOSC, V65, P1015, DOI 10.1016/j.gie.2006.12.065 | - |
dc.description.citedreference | Watanabe S, 2007, J GASTROENTEROL, V42, P267, DOI 10.1007/s00535-007-2033-0 | - |
dc.description.citedreference | Anderson JC, 2007, J CLIN GASTROENTEROL, V41, P285, DOI 10.1097/01.mcg.0000247988.96838.60 | - |
dc.description.citedreference | GIOVANNUCCI E, 2007, GASTROENTEROLOGY, V132, P2208, DOI 10.1053/j.gastro.2007.03.050 | - |
dc.description.citedreference | Howe HL, 2006, CANCER, V107, P1711, DOI 10.1002/cncr.22193 | - |
dc.description.citedreference | Yoshida I, 2006, CLIN GASTROENTEROL H, V4, P1225, DOI 10.1016/j.cgh.2006.07.002 | - |
dc.description.citedreference | Johnson KT, 2006, ACAD RADIOL, V13, P963, DOI 10.1016/j.acra.2006.04.008 | - |
dc.description.citedreference | Pischon T, 2006, J NATL CANCER I, V98, P920, DOI 10.1093/jnci/djj246 | - |
dc.description.citedreference | John BJ, 2006, ALIMENT PHARM THERAP, V23, P1511, DOI 10.1111/j.1365-2036.2006.02915.x | - |
dc.description.citedreference | Tabuchi M, 2006, WORLD J GASTROENTERO, V12, P1261 | - |
dc.description.citedreference | Frezza EE, 2006, GUT, V55, P285, DOI 10.1136/gut.2005.073163 | - |
dc.description.citedreference | Soon MS, 2005, AM J GASTROENTEROL, V100, P2749, DOI 10.1111/j.1572-0241.2005.00355.x | - |
dc.description.citedreference | Edwards BK, 2005, J NATL CANCER I, V97, P1407, DOI 10.1093/jnci/dji289 | - |
dc.description.citedreference | Wang YY, 2005, J GASTROEN HEPATOL, V20, P1410, DOI 10.1111/j.1440-1746.2005.03971.x | - |
dc.description.citedreference | Schoen RE, 2005, GASTROENTEROLOGY, V129, P464, DOI 10.1053/j.gastro.2005.05.051 | - |
dc.description.citedreference | Otake S, 2005, CLIN CANCER RES, V11, P3642 | - |
dc.description.citedreference | Kabir M, 2005, AM J PHYSIOL-ENDOC M, V288, pE454, DOI 10.1152/ajpendo.00203.2004 | - |
dc.description.citedreference | Raz I, 2005, DIABETES-METAB RES, V21, P3, DOI 10.1002/dmrr.493 | - |
dc.description.citedreference | MORITA T, 2005, ASIAN PAC J CANCER P, V6, P485 | - |
dc.description.citedreference | Limburg PJ, 2005, CANCER EPIDEM BIOMAR, V14, P133 | - |
dc.description.citedreference | Lin J, 2004, CANCER CAUSE CONTROL, V15, P581, DOI 10.1023/B:CACO.0000036168.23351.f1 | - |
dc.description.citedreference | Sass DA, 2004, AM J GASTROENTEROL, V99, P687, DOI 10.1111/j.1572-0241.2004.04136.x | - |
dc.description.citedreference | Moore LL, 2004, INT J OBESITY, V28, P559, DOI 10.1038/sj.ijo.0802606 | - |
dc.description.citedreference | Lieberman DA, 2003, JAMA-J AM MED ASSOC, V290, P2959, DOI 10.1001/jama.290.22.2959 | - |
dc.description.citedreference | Seril DN, 2003, CARCINOGENESIS, V24, P353 | - |
dc.description.citedreference | Goodpaster BH, 2002, CURR OPIN CLIN NUTR, V5, P481, DOI 10.1097/00075197-200209000-00005 | - |
dc.description.citedreference | Terry PD, 2002, GUT, V51, P191, DOI 10.1136/gut.51.2.191 | - |
dc.description.citedreference | Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486 | - |
dc.description.citedreference | Kaaks R, 2001, P NUTR SOC, V60, P91 | - |
dc.description.citedreference | Bergman RN, 2001, J INVEST MED, V49, P119 | - |
dc.description.citedreference | Park SK, 2000, J KOREAN MED SCI, V15, P690 | - |
dc.description.citedreference | *WHO IASO IOTF, 2000, AS PAC PERSP RED OB, P19 | - |
dc.description.citedreference | *WHO, 1999, RED MAT MORT, P9 | - |
dc.description.citedreference | Alberti KGMM, 1998, DIABETIC MED, V15, P539 | - |
dc.description.citedreference | Bird CL, 1998, AM J EPIDEMIOL, V147, P670 | - |
dc.description.citedreference | Martinez ME, 1997, J NATL CANCER I, V89, P948 | - |
dc.description.citedreference | Giovannucci E, 1996, CANCER CAUSE CONTROL, V7, P253 | - |
dc.description.citedreference | GIOVANNUCCI E, 1995, ANN INTERN MED, V122, P327 | - |
dc.description.citedreference | SHINCHI K, 1994, JPN J CANCER RES, V85, P479 | - |
dc.description.citedreference | WINAWER SJ, 1993, NEW ENGL J MED, V329, P1977 | - |
dc.description.citedreference | BOND JH, 1993, ANN INTERN MED, V119, P836 | - |
dc.description.citedreference | BJORK J, 1993, SCAND J GASTROENTERO, V28, P879 | - |
dc.description.citedreference | BAYERDORFFER E, 1993, ANN INTERN MED, V118, P481 | - |
dc.description.citedreference | SUADICANI P, 1993, SCAND J GASTROENTERO, V28, P285 | - |
dc.description.citedreference | BAYERDORFFER E, 1993, GASTROENTEROLOGY, V104, P137 | - |
dc.description.citedreference | THUN MJ, 1992, J NATL CANCER I, V84, P1491 | - |
dc.description.citedreference | AARONSON SA, 1991, SCIENCE, V254, P1146 | - |
dc.description.citedreference | LEE IM, 1991, J NATL CANCER I, V83, P1324 | - |
dc.description.citedreference | EDDY DM, 1990, ANN INTERN MED, V113, P373 | - |
dc.description.citedreference | WATKINS LF, 1990, INT J CANCER, V45, P372 | - |
dc.description.citedreference | VOGELSTEIN B, 1988, NEW ENGL J MED, V319, P525 | - |
dc.description.citedreference | MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412 | - |
dc.description.citedreference | TOKUNAGA K, 1983, INT J OBESITY, V7, P437 | - |
dc.description.citedreference | MUTO T, 1975, CANCER, V36, P2251 | - |
dc.description.citedreference | KOZUKA S, 1975, DIS COLON RECTUM, V18, P494 | - |
dc.description.tc | 16 | - |
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