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Orphan nuclear receptor small heterodimer partner inhibits angiotensin II- stimulated PAI-1 expression in vascular smooth muscle cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Kyeong-Min | - |
dc.contributor.author | Seo, Hye-Young | - |
dc.contributor.author | Kim, Mi-Kyung | - |
dc.contributor.author | Min, Ae-Kyung | - |
dc.contributor.author | Kim, Yoon-Nyun | - |
dc.contributor.author | Choi, Hueng-Sik | - |
dc.contributor.author | Park, Wan-Ju | - |
dc.contributor.author | Lee, In-Kyu | - |
dc.contributor.author | Park, Keun-Gyu | - |
dc.contributor.author | Lee, Ki-Up | - |
dc.contributor.author | Park, Young Joo | - |
dc.contributor.author | Ryu, Seong-Yeol | - |
dc.date.accessioned | 2012-05-29T07:49:14Z | - |
dc.date.available | 2012-05-29T07:49:14Z | - |
dc.date.issued | 2010-01-31 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.42 1; 21-29 | ko_KR |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76567 | - |
dc.description.abstract | Angiotensin 11 is a major effector molecule in the development of cardiovascular disease. In vascular smooth muscle cells (VSMCs), angiotensin 11 promotes cellular proliferation and extracellular matrix accumulation through the upregulation of plasminogen activator inhibitor-1 (PAI-1) expression. Previously, we demonstrated that small heterodimer partner (SHP) represses PAI-1 expression in the liver through the inhibition of TGF-beta signaling pathways. Here, we investigated whether SHP inhibited angiotensin II-stimulated PAI-1 expression in VSMCs. Adenovirus-mediated overexpression of SHP (Ad- SHP) in VSMCs inhibited angiotensin II- and TGF-beta-stimulated PAI-1 expression. Ad-SHP also inhibited angiotensin II-, TGF-beta- and Smad3-stimulated PAI-1 promoter activity, and angiotensin II-stimulated AP-1 activity. The level of PAI-1 expression was significantly higher in VSMCs of SHP(-/-) mice than wild type mice. Moreover, loss of SHP increased PAI-1 mRNA expression after angiotensin 11 treatment. These results suggest that SHP inhibits PAI-1 expression in VSMCs through the suppression of TGF-beta/Smad3 and AP-1 activity. Thus, agents that target the induction of SHP expression in VSMCs might help prevent the development and progression of atherosclerosis. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | ko_KR |
dc.subject | angiotensin II | ko_KR |
dc.subject | muscle, smooth, vascular | ko_KR |
dc.subject | atherosclerosis | ko_KR |
dc.subject | nuclear receptor subfamily 0, group B, member 2 | ko_KR |
dc.subject | transforming growth factor beta | ko_KR |
dc.subject | plasminogen activator inhibitor 1 | ko_KR |
dc.title | Orphan nuclear receptor small heterodimer partner inhibits angiotensin II- stimulated PAI-1 expression in vascular smooth muscle cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이경민 | - |
dc.contributor.AlternativeAuthor | 서혜영 | - |
dc.contributor.AlternativeAuthor | 김미경 | - |
dc.contributor.AlternativeAuthor | 민애경 | - |
dc.contributor.AlternativeAuthor | 류성열 | - |
dc.contributor.AlternativeAuthor | 김윤년 | - |
dc.contributor.AlternativeAuthor | 최흥식 | - |
dc.contributor.AlternativeAuthor | 이기업 | - |
dc.contributor.AlternativeAuthor | 박완주 | - |
dc.contributor.AlternativeAuthor | 박근규 | - |
dc.contributor.AlternativeAuthor | 이인규 | - |
dc.contributor.AlternativeAuthor | 박영주 | - |
dc.identifier.doi | 10.3858/emm.2010.42.1.002 | - |
dc.citation.journaltitle | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
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dc.description.tc | 2 | - |
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