S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Metabolic syndrome predicts mortality in non-diabetic patients on continuous ambulatory peritoneal dialysis
- Park, Jung Tak; Chang, Tae Ik; Kim, Dong Ki; Lee, Jung Eun; Kim, Hyun Wook; Park, Sun Young; Yoo, Tae-Hyun; Kang, Shin-Wook; Han, Dae-Suk; Kim, Eunyoung; Chang, Jae Hyun; Choi, Hoon Young
- Issue Date
- OXFORD UNIV PRESS
- NEPHROLOGY DIALYSIS TRANSPLANTATION; Vol.25 2; 599-604
- Background. Metabolic syndrome is associated with higher morbidity and mortality in the general population, but the corresponding effects in patients on dialysis have not been clearly defined. In this study, we prospectively investigated the effect of metabolic syndrome and its individual components on outcome in non-diabetic peritoneal dialysis (PD) patients. Method. The study subjects included 106 stable non-diabetic PD patients who had been on PD for > 3 months. We measured baseline characteristics, blood pressure, fasting blood glucose, lipid profiles and high-sensitivity CRP (hsCRP), and defined metabolic syndrome using the modified National Cholesterol Education Program (Adult Treatment Panel III) criteria. Mortality, technical failure and hospitalization were evaluated during the follow-up period. Results. Metabolic syndrome was present in 50 patients (47.2%), and these showed higher baseline hsCRP levels (0.67; 95% CI: 0.50-0.94 versus 1.78 mg/dl; 95% CI: 1.21-2.57; P < 0.001). Patients with metabolic syndrome experienced significantly lower 5-year survival rates than patients without (90% versus 67%, P = 0.02), although these groups did not differ in peritonitis rates, technical failure or hospitalization. A Cox proportional hazards analysis identified the following as predictors of mortality: metabolic syndrome (RR: 3.39; 95% CI: 1.16-9.94; P = 0.02), baseline albumin (RR: 0.06; 95% CI: 0.01-0.30; P = 0.001) and baseline hsCRP levels (RR: 1.14; 95% CI: 1.07-1.22; P < 0.001). Conclusion. Metabolic syndrome is prevalent and is a risk factor influencing long-term survival in non-diabetic PD patients.
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