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Prognostic Value of p53 and bcl-2 Expression in Patients Treated with Breast Conservative Therapy

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dc.contributor.authorKim, Kyubo-
dc.contributor.authorChie, Eui Kyu-
dc.contributor.authorHan, Wonshik-
dc.contributor.authorNoh, Dong-Young-
dc.contributor.authorPark, In Ae-
dc.contributor.authorOh, Do-Youn-
dc.contributor.authorIm, Seock-Ah-
dc.contributor.authorKim, Tae-You-
dc.contributor.authorBang, Yung-Jue-
dc.contributor.authorHa, Sung W.-
dc.date.accessioned2012-05-29T08:36:40Z-
dc.date.available2012-05-29T08:36:40Z-
dc.date.issued2010-02-
dc.identifier.citationJournal of Korean Medical Science, Vol.25 No.2, pp.235-239-
dc.identifier.issn1011-8934-
dc.identifier.other120744-
dc.identifier.urihttps://hdl.handle.net/10371/76573-
dc.description.abstractPrognostic value of p53 and bcl-2 expression on treatment outcome in breast cancer patients has been extensively evaluated, but the results were inconclusive. We evaluated the prognostic significance of these molecular markers in patients treated with breast conserving surgery and radiotherapy. One hundred patients whose immunostaining of p53 and bcl-2 expression was available among 125 patients who underwent radiotherapy after breast conserving surgery and axillary lymph node dissection were enrolled into this study. Eighty-seven patients also received adjuvant chemotherapy and/or hormonal therapy. Conventional clinicopathologic variables and treatment-related factors were also considered. The 5-yr loco-regional relapse-free and distant metastasis-free survival rates were 91.7% and 90.9%, respectively. On univariate analysis, age, T stage and the absence of bcl-2 & estrogen receptor (ER) expression were associated with loco-regional relapse-free survival. When incorporating these variables into Cox proportional hazard model, only bcl-2(-)/ER(-) phenotype was an adverse prognostic factor (P=0.018). As for the distant metastasis-free survival, age, T stage, and p53 expression were significant on univariate analysis. However, p53 expression was the only prognosticator on multivariate analysis (P=0.009). A bcl-2(-)/ER(-) phenotype and p53 expression are useful molecular markers predicting loco-regional relapse-free and distant metastasis-free survival, respectively, in patients treated with breast conserving surgery and radiotherapy.-
dc.language.isoenko_KR
dc.publisherKOREAN ACAD MEDICAL SCIENCESko_KR
dc.subjectBreast Neoplasms;bcl-2;p53-
dc.titlePrognostic Value of p53 and bcl-2 Expression in Patients Treated with Breast Conservative Therapy-
dc.typeArticle-
dc.contributor.AlternativeAuthor지의규-
dc.contributor.AlternativeAuthor한원식-
dc.contributor.AlternativeAuthor김태유-
dc.contributor.AlternativeAuthor임석아-
dc.contributor.AlternativeAuthor방영주-
dc.contributor.AlternativeAuthor노동영-
dc.contributor.AlternativeAuthor오도연-
dc.identifier.doi10.3346/jkms.2010.25.2.235-
dc.citation.journaltitleJournal of Korean Medical Science-
dc.description.citedreferenceFreedman GM, 2009, CANCER, V115, P946, DOI 10.1002/cncr.24094-
dc.description.citedreferenceTan DSP, 2008, BREAST CANCER RES TR, V111, P27, DOI 10.1007/s10549-007-9756-8-
dc.description.citedreferenceBidard FC, 2008, ANN ONCOL, V19, P1261, DOI 10.1093/annonc/mdn039-
dc.description.citedreferenceNguyen PL, 2008, J CLIN ONCOL, V26, P2373, DOI 10.1200/JCO.2007.14.4287-
dc.description.citedreferenceRolland P, 2007, INT J CANCER, V120, P1311, DOI 10.1002/ijc.22430-
dc.description.citedreferenceRakha EA, 2007, CANCER, V109, P25, DOI 10.1002/cncr.22381-
dc.description.citedreferenceHaffty BG, 2006, J CLIN ONCOL, V24, P5652, DOI 10.1200/JCO.2006.06.5664-
dc.description.citedreferenceNeri A, 2006, BREAST CANCER RES TR, V99, P77, DOI 10.1007/s10549-006-9183-2-
dc.description.citedreferenceCallagy GM, 2006, CLIN CANCER RES, V12, P2468, DOI 10.1158/1078-0432.CCR-05-2719-
dc.description.citedreferenceChoi DH, 2005, CANCER J, V11, P404-
dc.description.citedreferenceKim KJ, 2005, JPN J CLIN ONCOL, V35, P126, DOI 10.1093/jjcolyhi039-
dc.description.citedreferenceCianfrocca M, 2004, ONCOLOGIST, V9, P606-
dc.description.citedreferenceChen HHW, 2002, JPN J CLIN ONCOL, V32, P332-
dc.description.citedreferenceAlizadeh AA, 2001, J PATHOL, V195, P41-
dc.description.citedreferenceTurner BC, 2000, CANCER, V88, P1091-
dc.description.citedreferenceLe MG, 1999, INT J CANCER, V84, P562-
dc.description.citedreferenceElkhuizen PHM, 1999, INT J RADIAT ONCOL, V45, P73-
dc.description.citedreferenceBerardo MD, 1998, CANCER, V82, P1296-
dc.description.citedreferenceZhang GJ, 1997, JPN J CLIN ONCOL, V27, P371-
dc.description.citedreferenceNoguchi S, 1997, ONCOLOGY, V54, P468-
dc.description.citedreferenceSilvestrini R, 1997, J NATL CANCER I, V89, P639-
dc.description.citedreferenceBERGH J, 1995, NAT MED, V1, P1029-
dc.description.citedreferenceHELLEMANS P, 1995, BRIT J CANCER, V72, P354-
dc.description.citedreferenceGASPARINI G, 1995, CLIN CANCER RES, V1, P189-
dc.description.citedreferenceSILVESTRINI R, 1994, J NATL CANCER I, V86, P499-
dc.description.citedreferenceTHOR AD, 1992, J NATL CANCER I, V84, P845-
dc.description.tc3-
dc.identifier.scopusid2-s2.0-77951633260-
dc.citation.endpage239-
dc.citation.number2-
dc.citation.startpage235-
dc.citation.volume25-
dc.identifier.rimsid120744-
dc.identifier.sci000274413400007-
dc.identifier.kciidART001417170-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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