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Prognostic Factors Affecting the Outcome of Salvage Radiotherapy for Isolated Locoregional Recurrence After Mastectomy

Cited 13 time in Web of Science Cited 13 time in Scopus
Authors
Kim, Kyubo; Chie, Eui Kyu; Han, Wonshik; Noh, Dong-Young; Oh, Do-Youn; Im, Seock-Ah; Kim, Tae-You; Bang, Yung-Jue; Ha, Sung W.
Issue Date
2010-02
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
American Journal of Clinical Oncology, Vol.33 No.1, pp.23-27
Keywords
breast cancerlocoregional recurrencemastectomyradiotherapysystemic therapy
Abstract
Objectives: To evaluate the prognostic factors affecting the outcome of salvage radiotherapy for isolated locoregional recurrence after mastectomy. Methods: Between May 1988 and April 2002, 65 breast cancer patients Underwent radiotherapy as a component of salvage treatment for isolated locoregional recurrence after mastectomy. The sites Of failure were as follows: chest wall in 37 patients, regional lymph nodes (LNs) in 23 patients, and combined chest wall and LNs in 5 patients. None of the patients had previously been treated with radiation. Thirty-nine patients had surgical resection, and 55 patients received systemic chemotherapy and/or hormonal therapy for recurrent disease. In 51 cases (78.5%), the chest wall and ipsilateral regional lymphatics including supraclavicular, axillary, and internal mammary LNs were irradiated. Median close was 50.4 Gy (range: 50-71.5). Median duration of follow-up was 52 months (range: 2-206). Results: The 5-year overall survival rate was 48.1%. On multivariate analysis, patients without initial nodal involvement had better overall survival (P = 0.0118). The 5-year locoregional progress ion-free survival rate was 69.8%, and time to recurrence (>36 months vs <= 36 months) had an influence on the outcome with borderline significance (P = 0.0775). The 5-year distant metastasis-free survival rate was 42.1%. Lack of systemic therapy alter recurrence (P = 0.0089) and age <50 years at recurrence (P = 0.0145) were significant prognostic factors predicting poor distant metastasis-free survival. Conclusions: Radiotherapy for isolated locoregional relapse after inastectomy achieved locoregional control in about two-thirds of patients. Major pattern Of failure was distant relapse, and systemic therapy is warranted to prevent secondary dissemination.
ISSN
0277-3732
Language
English
URI
http://hdl.handle.net/10371/76578
DOI
https://doi.org/10.1097/COC.0b013e31819e2c02
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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