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A Regulatory Polymorphism at Position-309 in PTPRCAP Is Associated with Susceptibility to Diffuse-type Gastric Cancer and Gene Expression
DC Field | Value | Language |
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dc.contributor.author | Ju, Hyoungseok | - |
dc.contributor.author | Lim, Byungho | - |
dc.contributor.author | Kim, Minjin | - |
dc.contributor.author | Kim, Yong Sung | - |
dc.contributor.author | Ihm, Chunhwa | - |
dc.contributor.author | Han, Dong Soo | - |
dc.contributor.author | Choi, Bo Youl | - |
dc.contributor.author | Kang, Changwon | - |
dc.contributor.author | Yu, Hang-Jong | - |
dc.contributor.author | Noh, Seung-Moo | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.date.accessioned | 2012-05-30T01:37:40Z | - |
dc.date.available | 2012-05-30T01:37:40Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | NEOPLASIA; Vol.11 12; 1340-1347 | ko_KR |
dc.identifier.issn | 1522-8002 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76603 | - |
dc.description.abstract | PTPRCAP (CD45-AP) is a positive regulator of protein tyrosine phosphatase PTPRC (CD45), which activates Src family kinases implicated in tumorigenesis. Single-nucleotide polymorphism (SNP) rs869736 located at position -309 of the PTPRCAP promoter was associated with susceptibility to diffuse-type gastric cancer in the current case-control study. The minor-allele homozygote was significantly associated with a 2.5-fold increased susceptibility to diffuse-type gastric cancer (P = .0021, n = 252), but not to intestinal-type (P = .30, n = 178), versus the major-allele homozygote, when comparing unrelated Korean patients with healthy controls (n = 406). Nine other SNPs were in nearly perfect linkage disequilibrium (r(2) >= 0.97) with this SNP, exhibiting the same association, and spread out for 26 kb on chromosome 11q13.1 covering RPS6KB2, PTPRCAP, CORO1B, and GPR152. Among the four genes, however, only PTPRCAP expression was affected by haplotypes of the 10 SNPs. Endogenous transcript levels of PTPRCAP were linearly correlated with copy numbers (0, 1, and 2) of the risk-haplotype (P = .0060) in 12 lymphoblastoid cells derived from blood samples, but those of the other three genes were not. Furthermore, the cancer-risk, minor-allele T of rs869736 increased both promoter activity and specific nuclear protein-binding affinity than the nonrisk, major-allele G in luciferase reporter and electrophoretic mobility shift assays, respectively. Accordingly, the minor allele of rs869736 in the PTPRCAP promoter is associated with increased susceptibility to diffuse-type gastric cancer by increasing PTPRCAP expression, possibly leading to activation of the oncogenic Src family kinases. | ko_KR |
dc.description.sponsorship | 1This work was supported by a grant of the Korea Healthcare Technology R&D Project (A084417). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | NEOPLASIA PRESS | ko_KR |
dc.title | A Regulatory Polymorphism at Position-309 in PTPRCAP Is Associated with Susceptibility to Diffuse-type Gastric Cancer and Gene Expression | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 주형석 | - |
dc.contributor.AlternativeAuthor | 임병호 | - |
dc.contributor.AlternativeAuthor | 김민진 | - |
dc.contributor.AlternativeAuthor | 김용성 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.contributor.AlternativeAuthor | 임춘화 | - |
dc.contributor.AlternativeAuthor | 노승무 | - |
dc.contributor.AlternativeAuthor | 한동수 | - |
dc.contributor.AlternativeAuthor | 유항종 | - |
dc.contributor.AlternativeAuthor | 최보율 | - |
dc.contributor.AlternativeAuthor | 강창원 | - |
dc.identifier.doi | 10.1593/neo.91132 | - |
dc.citation.journaltitle | NEOPLASIA | - |
dc.description.citedreference | Mumm JB, 2008, ONCOGENE, V27, P5913, DOI 10.1038/onc.2008.275 | - |
dc.description.citedreference | Sakamoto H, 2008, NAT GENET, V40, P730, DOI 10.1038/ng.152 | - |
dc.description.citedreference | Menashe I, 2008, BMC GENET, V9, DOI 10.1186/1471-2156-9-36 | - |
dc.description.citedreference | Barraclough J, 2007, NEOPLASIA, V9, P745, DOI 10.1593/neo.07442 | - |
dc.description.citedreference | Leitenberg D, 2007, IMMUNOLOGY, V121, P545, DOI 10.1111/j.1365-2567.2007.02602.x | - |
dc.description.citedreference | Hold GL, 2007, GASTROENTEROLOGY, V132, P905, DOI 10.1053/j.gastro.2006.12.026 | - |
dc.description.citedreference | Wu CW, 2006, CANCER LETT, V242, P95, DOI 10.1016/j.canlet.2005.10.046 | - |
dc.description.citedreference | Ostman A, 2006, NAT REV CANCER, V6, P307, DOI 10.1038/nrc1837 | - |
dc.description.citedreference | Vauhkonen M, 2006, BEST PRACT RES CL GA, V20, P651, DOI 10.1016/j.bpg.2006.03.016 | - |
dc.description.citedreference | Buckland PR, 2005, HUM MUTAT, V26, P214, DOI 10.1002/humu.20207 | - |
dc.description.citedreference | Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457 | - |
dc.description.citedreference | Hatakeyama M, 2004, NAT REV CANCER, V4, P688, DOI 10.1038/nrc1433 | - |
dc.description.citedreference | Takeda A, 2004, BLOOD, V103, P3440 | - |
dc.description.citedreference | Tsugane S, 2004, BRIT J CANCER, V90, P128, DOI 10.1038/sj.bjc.6601511 | - |
dc.description.citedreference | Summy JM, 2003, CANCER METAST REV, V22, P337 | - |
dc.description.citedreference | Stephens M, 2003, AM J HUM GENET, V73, P1162 | - |
dc.description.citedreference | Yuasa Y, 2003, NAT REV CANCER, V3, P592, DOI 10.1038/nrc1141 | - |
dc.description.citedreference | Boussioutas A, 2003, CANCER RES, V63, P2569 | - |
dc.description.citedreference | Coussens LM, 2002, NATURE, V420, P860, DOI 10.1038/nature01322 | - |
dc.description.citedreference | Avizienyte E, 2002, NAT CELL BIOL, V4, P632, DOI 10.1038/ncb829 | - |
dc.description.citedreference | Irby RB, 2002, CANCER RES, V62, P2669 | - |
dc.description.citedreference | Higashi H, 2002, SCIENCE, V295, P683, DOI 10.1126/science.1067147 | - |
dc.description.citedreference | Peek RM, 2002, NAT REV CANCER, V2, P28, DOI 10.1038/nrc703 | - |
dc.description.citedreference | El-Omar EM, 2001, GUT, V48, P743, DOI 10.1136/gut.48.6.743 | - |
dc.description.citedreference | Penninger JM, 2001, NAT IMMUNOL, V2, P389 | - |
dc.description.citedreference | Stephens M, 2001, AM J HUM GENET, V68, P978 | - |
dc.description.citedreference | El-Omar EM, 2000, NATURE, V404, P398 | - |
dc.description.citedreference | PALLI D, 2000, J GASTROENTEROL S12, V35, P84 | - |
dc.description.citedreference | Owens DW, 2000, MOL BIOL CELL, V11, P51 | - |
dc.description.citedreference | Veillette A, 1999, J BIOL CHEM, V274, P14392 | - |
dc.description.citedreference | Motoya S, 1999, J BIOL CHEM, V274, P1407 | - |
dc.description.citedreference | Matsuda A, 1998, J EXP MED, V187, P1863 | - |
dc.description.citedreference | Guilford P, 1998, NATURE, V392, P402 | - |
dc.description.citedreference | KITAMURA K, 1995, J BIOL CHEM, V270, P21151 | - |
dc.description.citedreference | CORREA P, 1994, CANCER RES, V54, pS1941 | - |
dc.description.citedreference | TAKEDA A, 1994, J BIOL CHEM, V269, P2357 | - |
dc.description.citedreference | TROWBRIDGE IS, 1994, ANNU REV IMMUNOL, V12, P85 | - |
dc.description.citedreference | BEHRENS J, 1993, J CELL BIOL, V120, P757 | - |
dc.description.citedreference | CORREA P, 1992, CANCER RES, V52, P6735 | - |
dc.description.citedreference | MUSTELIN T, 1992, EUR J IMMUNOL, V22, P1173 | - |
dc.description.citedreference | MUSTELIN T, 1989, P NATL ACAD SCI USA, V86, P6302 | - |
dc.description.citedreference | CORREA P, 1988, CANCER RES, V48, P3554 | - |
dc.description.citedreference | HUNTER T, 1985, ANNU REV BIOCHEM, V54, P897 | - |
dc.description.citedreference | LAUREN P, 1965, ACTA PATHOL MIC SC, V64, P31 | - |
dc.description.tc | 4 | - |
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