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Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers

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dc.contributor.authorKim, Jung Ho-
dc.contributor.authorShin, So Hyun-
dc.contributor.authorKwon, Hyeong Ju-
dc.contributor.authorCho, Nam Yun-
dc.contributor.authorKang, Gyeong Hoon-
dc.date.accessioned2012-05-30T02:21:52Z-
dc.date.available2012-05-30T02:21:52Z-
dc.date.issued2009-12-
dc.identifier.citationVIRCHOWS ARCHIV; Vol.455 6; 485-494ko_KR
dc.identifier.issn0945-6317-
dc.identifier.urihttps://hdl.handle.net/10371/76609-
dc.description.abstractCpG island methylator phenotype (CIMP) refers to a subset of colorectal cancers (CRCs) that are characterized by concordant hypermethylation of multiple CpG island loci. CIMP+ CRCs have peculiar clinicopathological features. However, controversy exists over prognostic implications of CIMP in CRCs. We analyzed 320 cases of CRCs for their CIMP status using the MethyLight assay and determined clinicopathological features and prognostic implications of CIMP alone or in combination with microsatellite instability (MSI). With methylation of five or more markers among eight markers examined, CIMP+ tumors were significantly associated with female gender, proximal tumor location, poor differentiation, nodal metastasis, more advanced cancer, BRAF mutations, MSI, and poor prognosis (all P values < 0.05). Ogino`s combined eight-marker panel outperformed the Ogino and the Laird five-marker panels in detecting these features. Of the four molecular subtypes generated by the combination of CIMP and MSI status, the CIMP+/MSI- subtype showed the worst clinical outcome (P = 0.0003). However, poor prognosis of CIMP+/MSI- subtype was found to be attributed to BRAF mutation. In conclusion, the CIMP+/MSI- subtype tends to present with distinct clinicopathological and molecular features and shows the worst clinical outcome among the four molecular subtypes of CRCs.ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGERko_KR
dc.subjectColon cancerko_KR
dc.subjectMicrosatellite instabilityko_KR
dc.subjectCpG island methylator phenotypeko_KR
dc.subjectDNA methylationko_KR
dc.titlePrognostic implications of CpG island hypermethylator phenotype in colorectal cancersko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김정호-
dc.contributor.AlternativeAuthor신소현-
dc.contributor.AlternativeAuthor권형주-
dc.contributor.AlternativeAuthor조남윤-
dc.contributor.AlternativeAuthor강경훈-
dc.identifier.doi10.1007/s00428-009-0857-0-
dc.citation.journaltitleVIRCHOWS ARCHIV-
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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