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Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Ho | - |
dc.contributor.author | Shin, So Hyun | - |
dc.contributor.author | Kwon, Hyeong Ju | - |
dc.contributor.author | Cho, Nam Yun | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.date.accessioned | 2012-05-30T02:21:52Z | - |
dc.date.available | 2012-05-30T02:21:52Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | VIRCHOWS ARCHIV; Vol.455 6; 485-494 | ko_KR |
dc.identifier.issn | 0945-6317 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76609 | - |
dc.description.abstract | CpG island methylator phenotype (CIMP) refers to a subset of colorectal cancers (CRCs) that are characterized by concordant hypermethylation of multiple CpG island loci. CIMP+ CRCs have peculiar clinicopathological features. However, controversy exists over prognostic implications of CIMP in CRCs. We analyzed 320 cases of CRCs for their CIMP status using the MethyLight assay and determined clinicopathological features and prognostic implications of CIMP alone or in combination with microsatellite instability (MSI). With methylation of five or more markers among eight markers examined, CIMP+ tumors were significantly associated with female gender, proximal tumor location, poor differentiation, nodal metastasis, more advanced cancer, BRAF mutations, MSI, and poor prognosis (all P values < 0.05). Ogino`s combined eight-marker panel outperformed the Ogino and the Laird five-marker panels in detecting these features. Of the four molecular subtypes generated by the combination of CIMP and MSI status, the CIMP+/MSI- subtype showed the worst clinical outcome (P = 0.0003). However, poor prognosis of CIMP+/MSI- subtype was found to be attributed to BRAF mutation. In conclusion, the CIMP+/MSI- subtype tends to present with distinct clinicopathological and molecular features and shows the worst clinical outcome among the four molecular subtypes of CRCs. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.subject | Colon cancer | ko_KR |
dc.subject | Microsatellite instability | ko_KR |
dc.subject | CpG island methylator phenotype | ko_KR |
dc.subject | DNA methylation | ko_KR |
dc.title | Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김정호 | - |
dc.contributor.AlternativeAuthor | 신소현 | - |
dc.contributor.AlternativeAuthor | 권형주 | - |
dc.contributor.AlternativeAuthor | 조남윤 | - |
dc.contributor.AlternativeAuthor | 강경훈 | - |
dc.identifier.doi | 10.1007/s00428-009-0857-0 | - |
dc.citation.journaltitle | VIRCHOWS ARCHIV | - |
dc.description.citedreference | Vilkin A, 2009, CANCER, V115, P760, DOI 10.1002/cncr.24019 | - |
dc.description.citedreference | Ogino S, 2009, GUT, V58, P90, DOI 10.1136/gut.2008.155473 | - |
dc.description.citedreference | Barault L, 2008, CANCER RES, V68, P8541, DOI 10.1158/0008-5472.CAN-08-1171 | - |
dc.description.citedreference | Cheng YW, 2008, CLIN CANCER RES, V14, P6005, DOI 10.1158/1078-0432.CCR-08-0216 | - |
dc.description.citedreference | Lee S, 2008, ARCH PATHOL LAB MED, V132, P1657 | - |
dc.description.citedreference | Nagasaka T, 2008, GASTROENTEROLOGY, V134, P1950, DOI 10.1053/j.gastro.2008.02.094 | - |
dc.description.citedreference | Yoo EJ, 2008, VIRCHOWS ARCH, V452, P515, DOI 10.1007/s00428-008-0596-7 | - |
dc.description.citedreference | Lee S, 2008, PATHOL INT, V58, P104, DOI 10.1111/j.1440-1827.2007.02197.x | - |
dc.description.citedreference | Kang GH, 2008, LAB INVEST, V88, P161, DOI 10.1038/labinvest.3700707 | - |
dc.description.citedreference | Ogino S, 2008, J MOL DIAGN, V10, P13, DOI 10.2353/jmoldx.2008.070082 | - |
dc.description.citedreference | Kakar S, 2008, HUM PATHOL, V39, P30, DOI 10.1016/j.humpath.2007.06.002 | - |
dc.description.citedreference | Shen LL, 2007, P NATL ACAD SCI USA, V104, P18654, DOI 10.1073/pnas.0704652104 | - |
dc.description.citedreference | Wood LD, 2007, SCIENCE, V318, P1108, DOI 10.1126/science.1145720 | - |
dc.description.citedreference | Shen L, 2007, CLIN CANCER RES, V13, P6093, DOI 10.1158/1078-0432.CCR-07-1011 | - |
dc.description.citedreference | Schuebel KE, 2007, PLOS GENET, V3, P1709, DOI 10.1371/journal.pgen.0030157 | - |
dc.description.citedreference | Ogino S, 2007, J MOL DIAGN, V9, P305, DOI 10.2353/jmoldx.2007.060170 | - |
dc.description.citedreference | Samowitz WS, 2007, MOL CANCER RES, V5, P165, DOI 10.1158/1541-7786.MCR-06-0398 | - |
dc.description.citedreference | Goel A, 2007, GASTROENTEROLOGY, V132, P127, DOI 10.1053/j.gastro.2006.09.018 | - |
dc.description.citedreference | Ogino S, 2006, J MOL DIAGN, V8, P582, DOI 10.2353/j.moldx.2006.060082 | - |
dc.description.citedreference | Jass JR, 2006, HISTOPATHOLOGY, V49, P121, DOI 10.1111/j.1365-2559.2006.02466.x | - |
dc.description.citedreference | Weisenberger DJ, 2006, NAT GENET, V38, P787, DOI 10.1038/ng1834 | - |
dc.description.citedreference | Ogino S, 2006, GUT, V55, P1000, DOI 10.1136/gut.2005.082933 | - |
dc.description.citedreference | Tanaka H, 2006, INT J CANCER, V118, P2765, DOI 10.1002/ijc.21701 | - |
dc.description.citedreference | Chang SC, 2006, INT J CANCER, V118, P1721, DOI 10.1002/ijc.21563 | - |
dc.description.citedreference | Samowitz WS, 2005, CANCER RES, V65, P6063 | - |
dc.description.citedreference | Young J, 2005, CLIN GASTROENTEROL H, V3, P254, DOI 10.1053/S1542-3565(04)00673-1 | - |
dc.description.citedreference | Weisenberger DJ, 2005, NUCLEIC ACIDS RES, V33, P6823, DOI 10.1093/nar/gki987 | - |
dc.description.citedreference | Nagasaka T, 2004, J CLIN ONCOL, V22, P4584, DOI 10.1200/JCO.2004.02.154 | - |
dc.description.citedreference | Fransen K, 2004, CARCINOGENESIS, V25, P527, DOI 10.1093/carcin/bgh049 | - |
dc.description.citedreference | Oliveira C, 2003, ONCOGENE, V22, P9192, DOI 10.1038/sj.onc.1207061 | - |
dc.description.citedreference | Ward RL, 2003, J CLIN ONCOL, V21, P3729, DOI 10.1200/JCO.2003.03.123 | - |
dc.description.citedreference | Goel A, 2003, CANCER RES, V63, P1608 | - |
dc.description.citedreference | Yuen ST, 2002, CANCER RES, V62, P6451 | - |
dc.description.citedreference | Rajagopalan H, 2002, NATURE, V418, P934, DOI 10.1038/418934a | - |
dc.description.citedreference | Cunningham JM, 2001, AM J HUM GENET, V69, P780 | - |
dc.description.citedreference | Rashid A, 2001, AM J PATHOL, V159, P1129 | - |
dc.description.citedreference | Esteller M, 2001, CANCER RES, V61, P3225 | - |
dc.description.citedreference | Kuismanen SA, 2000, AM J PATHOL, V156, P1773 | - |
dc.description.citedreference | Georgiades IB, 1999, ONCOGENE, V18, P7933 | - |
dc.description.citedreference | Bird AP, 1999, CELL, V99, P451 | - |
dc.description.citedreference | Toyota M, 1999, P NATL ACAD SCI USA, V96, P8681 | - |
dc.description.citedreference | Cunningham JM, 1998, CANCER RES, V58, P3455 | - |
dc.description.citedreference | Herman JG, 1998, P NATL ACAD SCI USA, V95, P6870 | - |
dc.description.citedreference | Baylin SB, 1998, ADV CANCER RES, V72, P141 | - |
dc.description.tc | 27 | - |
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