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Multifarious proteomic signatures and regional heterogeneity in glioblastomas

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dc.contributor.authorPark, Chul-Kee-
dc.contributor.authorJung, Ji Hye-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorJung, Hee-Won-
dc.contributor.authorCho, Byung-Kyu-
dc.date.accessioned2012-05-30T07:27:37Z-
dc.date.available2012-05-30T07:27:37Z-
dc.date.issued2009-08-
dc.identifier.citationJOURNAL OF NEURO-ONCOLOGY; Vol.94 1; 31-39ko_KR
dc.identifier.issn0167-594X-
dc.identifier.urihttps://hdl.handle.net/10371/76629-
dc.description.abstractTo investigate the underlying intratumoral diversity of molecular profiles in glioblastomas, a proteomic approach was introduced to compare samples from regions of different histological grade. Using two-dimensional gel electrophoresis (2DE) with matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), we compared prospectively collected tissue samples of different histological grade areas of three glioblastoma patients. Consistent results showing relatively high expression of ubiquitin carboxyl-terminal esterase L1 in low-histological-grade areas (Grade 2 > Grades 3 and 4) and high expression of transthyretin in high-histological-grade areas (Grade 2 < Grades 3 and 4) were demonstrated. These results were confirmed by western blot (WB) analysis and immunohistochemical staining. This study provided the evidence of multifarious proteomic signatures according to regional and histological heterogeneity in glioblastomas.ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGERko_KR
dc.subjectProteomicsko_KR
dc.subjectUbiquitin carboxyl-terminal esterase L1ko_KR
dc.subjectTransthyretinko_KR
dc.subjectHeterogeneityko_KR
dc.subjectMass spectrometryko_KR
dc.subjectGlioblastomako_KR
dc.titleMultifarious proteomic signatures and regional heterogeneity in glioblastomasko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박철기-
dc.contributor.AlternativeAuthor정지혜-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor정희원-
dc.contributor.AlternativeAuthor조병규-
dc.identifier.doi10.1007/s11060-009-9805-8-
dc.citation.journaltitleJOURNAL OF NEURO-ONCOLOGY-
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