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Methylation Status of the O6-Methylguanine-Deoxyribonucleic Acid Methyltransferase Gene Promoter in World Health Organization Grade III Gliomas

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dc.contributor.authorYang, Seung-Heon-
dc.contributor.authorKim, Yong Hwy-
dc.contributor.authorKim, Jin Wook-
dc.contributor.authorPark, Chul-Kee-
dc.contributor.authorJung, Hee-Won-
dc.contributor.authorPark, Sung-Hye-
dc.date.accessioned2012-05-31T00:22:01Z-
dc.date.available2012-05-31T00:22:01Z-
dc.date.issued2009-10-
dc.identifier.citationJOURNAL OF KOREAN NEUROSURGICAL SOCIETY; Vol.46 4; 385-388ko_KR
dc.identifier.issn2005-3711-
dc.identifier.urihttps://hdl.handle.net/10371/76633-
dc.description.abstractObjective : We analyzed the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter in World Health Organization (WHO) grade III gliomas in association with other molecular markers to evaluate their prevalence. Methods : The samples of a total of 36 newly WHO grade III glioma patients including 19 anaplastic oligodendrogliomas (AO), 7 anaplastic oligoastrocytomas (AOA), and 10 anaplastic astrocytomas (AA) were analyzed. The methylation status of the MGMT gene promoter was confirmed by methylation-specific polymerase chain reaction. The 1p/19q chromosomal deletion status and EGFR amplification were assessed by Fluorescence In-Situ Hybridization. MGMT, EGFR, EGFRvIII, and p53 expression were analyzed by immunohistochemical staining. Results : The MGMT gene promoter was methylated in 32 (88.9%) and unmethylated in 4 (11.2%). Among them, all of the AO and AOA had methylated MGMT gene promoter without exception. Significant associations between MGMT gene promoter hypermethylation and 1p/19q deletion was observed (p = 0.003). Other molecular markers failed to show significant associations between MGMT gene promoter statuses. Conclusion : There was extensive epigenetic silencing of MGMT gene in high grade gliomas with oligodendroglial component. Together with frequent 1p/19q co-deletion in oligodendroglial tumors, this may add plausible explanations supporting the relative favorable prognosis in oligodendroglial tumors compared with pure astrocytic tumors.ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN NEUROSURGICAL SOCko_KR
dc.subjectMGMT gene promoterko_KR
dc.subjectMethylation-specific PCRko_KR
dc.subjectOligodendrogliomako_KR
dc.subjectMethylationko_KR
dc.subject1p/19qko_KR
dc.titleMethylation Status of the O6-Methylguanine-Deoxyribonucleic Acid Methyltransferase Gene Promoter in World Health Organization Grade III Gliomasko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor양승훈-
dc.contributor.AlternativeAuthor김용휘-
dc.contributor.AlternativeAuthor김진욱-
dc.contributor.AlternativeAuthor박철기-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor정희원-
dc.identifier.doi10.3340/jkns.2009.46.4.385-
dc.citation.journaltitleJOURNAL OF KOREAN NEUROSURGICAL SOCIETY-
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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