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Natural killer T cells are dispensable in the development of allergen-induced airway hyperresponsiveness, inflammation and remodelling in a mouse model of chronic asthma
DC Field | Value | Language |
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dc.contributor.author | Koh, Y-I. | - |
dc.contributor.author | Shim, J-U. | - |
dc.contributor.author | Lee, J-H. | - |
dc.contributor.author | Chung, I-J. | - |
dc.contributor.author | Rhee, J. H. | - |
dc.contributor.author | Chung, D. H. | - |
dc.contributor.author | Wi, J-O. | - |
dc.contributor.author | Lee, H. C. | - |
dc.contributor.author | Min, J-J. | - |
dc.date.accessioned | 2012-05-31T02:10:42Z | - |
dc.date.available | 2012-05-31T02:10:42Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | CLINICAL AND EXPERIMENTAL IMMUNOLOGY; Vol.161 1; 159-170 | ko_KR |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76654 | - |
dc.description.abstract | P>Natural killer T (NK T) cells have been shown to play an essential role in the development of allergen-induced airway hyperresponsiveness (AHR) and/or airway inflammation in mouse models of acute asthma. Recently, NK T cells have been reported to be required for the development of AHR in a virus induced chronic asthma model. We investigated whether NK T cells were required for the development of allergen-induced AHR, airway inflammation and airway remodelling in a mouse model of chronic asthma. CD1d-/- mice that lack NK T cells were used for the experiments. In the chronic model, AHR, eosinophilic inflammation, remodelling characteristics including mucus metaplasia, subepithelial fibrosis and increased mass of the airway smooth muscle, T helper type 2 (Th2) immune response and immunoglobulin (Ig)E production were equally increased in both CD1d-/- mice and wild-type mice. However, in the acute model, AHR, eosinophilic inflammation, Th2 immune response and IgE production were significantly decreased in the CD1d-/- mice compared to wild-type. CD1d-dependent NK T cells may not be required for the development of allergen-induced AHR, eosinophilic airway inflammation and airway remodelling in chronic asthma model, although they play a role in the development of AHR and eosinophilic inflammation in acute asthma model. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL | ko_KR |
dc.subject | airway inflammation | ko_KR |
dc.subject | natural killer T cells | ko_KR |
dc.subject | airway remodelling | ko_KR |
dc.subject | asthma | ko_KR |
dc.subject | airway responsiveness | ko_KR |
dc.title | Natural killer T cells are dispensable in the development of allergen-induced airway hyperresponsiveness, inflammation and remodelling in a mouse model of chronic asthma | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1111/j.1365-2249.2010.04151.x | - |
dc.citation.journaltitle | CLINICAL AND EXPERIMENTAL IMMUNOLOGY | - |
dc.description.citedreference | Doherty TA, 2009, AM J PHYSIOL-LUNG C, V296, pL229, DOI 10.1152/ajplung.90543.2008 | - |
dc.description.citedreference | Folli C, 2008, CURR OPIN ALLERGY CL, V8, P367, DOI 10.1097/ACI.0b013e32830a7086 | - |
dc.description.citedreference | Koh YI, 2008, J IMMUNOL, V181, P4560 | - |
dc.description.citedreference | Siddiqui S, 2008, J ALLERGY CLIN IMMUN, V122, P335, DOI 10.1016/j.jaci.2008.05.020 | - |
dc.description.citedreference | Meurs H, 2008, EUR RESPIR J, V32, P487, DOI 10.1183/09031936.00023608 | - |
dc.description.citedreference | Kondo Y, 2008, INT IMMUNOL, V20, P791, DOI 10.1093/intimm/dxn037 | - |
dc.description.citedreference | Kim EY, 2008, NAT MED, V14, P633, DOI 10.1038/nm1770 | - |
dc.description.citedreference | Pichavant M, 2008, J EXP MED, V205, P385, DOI 10.1084/jem.20071507 | - |
dc.description.citedreference | Holgate ST, 2007, J ALLERGY CLIN IMMUN, V120, P1233, DOI 10.1016/j.jaci.2007.10.025 | - |
dc.description.citedreference | Kim SJ, 2007, J KOREAN MED SCI, V22, P183 | - |
dc.description.citedreference | HOYMANN HG, 2007, J PHARMACOL TOXICOL, V55, P16, DOI 10.1016/j.vascn.2006.04.006 | - |
dc.description.citedreference | Umetsu DT, 2006, NAT REV IMMUNOL, V6, P953, DOI 10.1038/nri1968 | - |
dc.description.citedreference | Das J, 2006, NAT MED, V12, P1345 | - |
dc.description.citedreference | Cockcroft DW, 2006, J ALLERGY CLIN IMMUN, V118, P551, DOI 10.1016/j.jaci.2006.07.012 | - |
dc.description.citedreference | Akbari O, 2006, NEW ENGL J MED, V354, P1117 | - |
dc.description.citedreference | Meyer EH, 2006, P NATL ACAD SCI USA, V103, P2782, DOI 10.1073/pnas.0510282103 | - |
dc.description.citedreference | Pham-Thi N, 2006, J ALLERGY CLIN IMMUN, V117, P217, DOI 10.1016/j.jaci.2005.09.052 | - |
dc.description.citedreference | Parekh VV, 2005, J CLIN INVEST, V115, P2572, DOI 10.1172/JCI24762 | - |
dc.description.citedreference | Duarte N, 2004, J IMMUNOL, V173, P3112 | - |
dc.description.citedreference | Lisbonne M, 2003, J IMMUNOL, V171, P1637 | - |
dc.description.citedreference | Akbari O, 2003, NAT MED, V9, P582, DOI 10.1038/nm851 | - |
dc.description.citedreference | Wen FQ, 2003, CHEST, V123, p372S | - |
dc.description.citedreference | Komai M, 2003, BRIT J PHARMACOL, V138, P912, DOI 10.1038/sj.bjp.0705105 | - |
dc.description.citedreference | Kumar RK, 2002, CLIN EXP ALLERGY, V32, P1104 | - |
dc.description.citedreference | Lee PT, 2002, J EXP MED, V195, P637 | - |
dc.description.citedreference | Leong KP, 2001, ANN ALLERG ASTHMA IM, V87, P96 | - |
dc.description.citedreference | Busse WW, 2001, NEW ENGL J MED, V344, P350 | - |
dc.description.citedreference | Matsuda JL, 2000, J EXP MED, V192, P741 | - |
dc.description.citedreference | Faul JL, 1999, AM J RESP CRIT CARE, V160, P1457 | - |
dc.description.citedreference | Sakai K, 1999, CLIN EXP IMMUNOL, V118, P9 | - |
dc.description.citedreference | Cui JQ, 1999, J EXP MED, V190, P783 | - |
dc.description.citedreference | Yiamouyiannis CA, 1999, AM J PATHOL, V154, P1911 | - |
dc.description.citedreference | Grunig G, 1998, SCIENCE, V282, P2261 | - |
dc.description.citedreference | Smiley ST, 1997, SCIENCE, V275, P977 | - |
dc.description.citedreference | YOSHIMOTO T, 1995, SCIENCE, V270, P1845 | - |
dc.description.citedreference | HARGREAVE FE, 1986, J ALLERGY CLIN IMMUN, V78, P825 | - |
dc.description.tc | 0 | - |
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