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Natural killer T cells are dispensable in the development of allergen-induced airway hyperresponsiveness, inflammation and remodelling in a mouse model of chronic asthma

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dc.contributor.authorKoh, Y-I.-
dc.contributor.authorShim, J-U.-
dc.contributor.authorLee, J-H.-
dc.contributor.authorChung, I-J.-
dc.contributor.authorRhee, J. H.-
dc.contributor.authorChung, D. H.-
dc.contributor.authorWi, J-O.-
dc.contributor.authorLee, H. C.-
dc.contributor.authorMin, J-J.-
dc.date.accessioned2012-05-31T02:10:42Z-
dc.date.available2012-05-31T02:10:42Z-
dc.date.issued2010-07-
dc.identifier.citationCLINICAL AND EXPERIMENTAL IMMUNOLOGY; Vol.161 1; 159-170ko_KR
dc.identifier.issn0009-9104-
dc.identifier.urihttps://hdl.handle.net/10371/76654-
dc.description.abstractP>Natural killer T (NK T) cells have been shown to play an essential role in the development of allergen-induced airway hyperresponsiveness (AHR) and/or airway inflammation in mouse models of acute asthma. Recently, NK T cells have been reported to be required for the development of AHR in a virus induced chronic asthma model. We investigated whether NK T cells were required for the development of allergen-induced AHR, airway inflammation and airway remodelling in a mouse model of chronic asthma. CD1d-/- mice that lack NK T cells were used for the experiments. In the chronic model, AHR, eosinophilic inflammation, remodelling characteristics including mucus metaplasia, subepithelial fibrosis and increased mass of the airway smooth muscle, T helper type 2 (Th2) immune response and immunoglobulin (Ig)E production were equally increased in both CD1d-/- mice and wild-type mice. However, in the acute model, AHR, eosinophilic inflammation, Th2 immune response and IgE production were significantly decreased in the CD1d-/- mice compared to wild-type. CD1d-dependent NK T cells may not be required for the development of allergen-induced AHR, eosinophilic airway inflammation and airway remodelling in chronic asthma model, although they play a role in the development of AHR and eosinophilic inflammation in acute asthma model.ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-BLACKWELLko_KR
dc.subjectairway inflammationko_KR
dc.subjectnatural killer T cellsko_KR
dc.subjectairway remodellingko_KR
dc.subjectasthmako_KR
dc.subjectairway responsivenessko_KR
dc.titleNatural killer T cells are dispensable in the development of allergen-induced airway hyperresponsiveness, inflammation and remodelling in a mouse model of chronic asthmako_KR
dc.typeArticleko_KR
dc.identifier.doi10.1111/j.1365-2249.2010.04151.x-
dc.citation.journaltitleCLINICAL AND EXPERIMENTAL IMMUNOLOGY-
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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