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Snail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomas

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dc.contributor.authorMyung, Jaekyung-
dc.contributor.authorCho, Byung-Kyu-
dc.contributor.authorKim, Young-Soon-
dc.contributor.authorPark, Sung-Hye-
dc.date.accessioned2012-05-31T04:46:23Z-
dc.date.available2012-05-31T04:46:23Z-
dc.date.issued2010-06-
dc.identifier.citationNEUROPATHOLOGY; Vol.30 3; 224-231ko_KR
dc.identifier.issn0919-6544-
dc.identifier.urihttps://hdl.handle.net/10371/76666-
dc.description.abstractThe transcriptional factor Snail and enzyme cyclo-oxygenase-2 (Cox-2) are suggested to be important effectors of invasiveness and tumorigenesis in various tumors. Tumors of higher grade have the propensity for tumor cell migration and invasiveness. This study was performed in order to evaluate the association between Snail and Cox-2 expressions and their values as prognostic factors in various grades of glioma, Specimens of 56 patients with glioma were used in the study. Univariate analysis showed that WHO tumor grade, and expressions of Snail and Cox-2 were significant prognostic factors affecting overall and disease progression-free survival rates. In the multivariate analysis by Cox regression model, only WHO tumor grade was shown to be a significant independent prognostic factor of overall and progression-free survival rates. In conclusion, Snail and Cox-2 expressions were associated with WHO grade in gliomas and may be used as prognostic indicators.ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-BLACKWELLko_KR
dc.subjectCox-2ko_KR
dc.subjectgliomako_KR
dc.subjectprognostic factorko_KR
dc.subjectSnailko_KR
dc.subjectimmunohistochemistryko_KR
dc.titleSnail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomasko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor명재경-
dc.contributor.AlternativeAuthor조병규-
dc.contributor.AlternativeAuthor김영순-
dc.contributor.AlternativeAuthor박성혜-
dc.identifier.doi10.1111/j.1440-1789.2009.01072.x-
dc.citation.journaltitleNEUROPATHOLOGY-
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