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Identification of the KAI1 metastasis suppressor gene as a hypoxia target gene

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dc.contributor.authorKim, Bogyou-
dc.contributor.authorBoo, Kyungjin-
dc.contributor.authorLee, Jason S.-
dc.contributor.authorKim, Keun Il-
dc.contributor.authorCho, Hyun-Jai-
dc.contributor.authorKim, Hyo-Soo-
dc.contributor.authorBaek, Sung Hee-
dc.contributor.authorPark, Young-Bae-
dc.contributor.authorKim, Woo Ho-
dc.date.accessioned2012-05-31T06:22:03Z-
dc.date.available2012-05-31T06:22:03Z-
dc.date.issued2010-02-26-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Vol.393 1; 179-184ko_KR
dc.identifier.issn0006-291X-
dc.identifier.urihttps://hdl.handle.net/10371/76687-
dc.description.abstractKAI1 is a metastasis suppressor gene known to inhibit cancer metastasis without affecting primary tumorigenicity. Although KAI1 expression has been reported to undergo transcriptional regulation, how its expression is up- or down-regulated by specific upstream signaling pathways has not been studied in detail. In this study, we characterized the regulatory elements within the 500 bp upstream region of mouse KAI1 gene and identified a functional hypoxia-response element (HRE) within the promoter region. Hypoxia-dependent induction of KAI1 was directly mediated by hypoxia-inducible factor (HIF)-1 alpha binding on the promoter, which subsequently caused increased recruitment of RNA polymerase II for transcriptional activation. The failure of HIF-1 alpha recruitment to the KAI1 promoter was observed in Hif-1 alpha knockout mouse embryonic fibroblasts. Furthermore, KAI1 protein synthesis was markedly increased in ischemic tissues, suggesting that KAI1 is a hypoxia target gene in vivo. (C) 2010 Elsevier Inc. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEko_KR
dc.subjectCancerko_KR
dc.subjectMetastasisko_KR
dc.subjectTranscriptionko_KR
dc.subjectHypoxiako_KR
dc.subjectSuppressorko_KR
dc.titleIdentification of the KAI1 metastasis suppressor gene as a hypoxia target geneko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김보규-
dc.contributor.AlternativeAuthor부경진-
dc.contributor.AlternativeAuthor김근일-
dc.contributor.AlternativeAuthor김우호-
dc.contributor.AlternativeAuthor조현재-
dc.contributor.AlternativeAuthor박영배-
dc.contributor.AlternativeAuthor김효수-
dc.contributor.AlternativeAuthor백성희-
dc.identifier.doi10.1016/j.bbrc.2010.01.118-
dc.citation.journaltitleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.description.citedreferenceHenze AT, 2010, CANCER RES, V70, P357, DOI 10.1158/0008-5472.CAN-09-1876-
dc.description.citedreferenceZoller M, 2009, NAT REV CANCER, V9, P40, DOI 10.1038/nrc2543-
dc.description.citedreferenceHahn JY, 2008, J AM COLL CARDIOL, V51, P933, DOI 10.1016/j.jacc.2007.11.040-
dc.description.citedreferenceTsai YC, 2007, NAT MED, V13, P1504, DOI 10.1038/nm1686-
dc.description.citedreferenceHahn JY, 2006, J BIOL CHEM, V281, P30979, DOI 10.1074/jbc.M603916200-
dc.description.citedreferenceBandyopadhyay S, 2006, NAT MED, V12, P933, DOI 10.1038/nm1444-
dc.description.citedreferencePouyssegur J, 2006, NATURE, V441, P437, DOI 10.1038/nature04871-
dc.description.citedreferenceKim JH, 2005, NATURE, V434, P921, DOI 10.1038/nature03452-
dc.description.citedreferenceMarreiros A, 2005, ONCOGENE, V24, P637, DOI 10.1038/sj.onc.1208216-
dc.description.citedreferenceManalo DJ, 2005, BLOOD, V105, P659, DOI 10.1182/blood-2004-07-2958-
dc.description.citedreferenceKoshiji M, 2004, EMBO J, V23, P1949, DOI 10.1038/sj.emboj.7600196-
dc.description.citedreferenceSemenza GL, 2003, NAT REV CANCER, V3, P721, DOI 10.1038/nrc1187-
dc.description.citedreferencePugh CW, 2003, NAT MED, V9, P677-
dc.description.citedreferenceMack FA, 2003, CANCER CELL, V3, P75-
dc.description.citedreferenceWenger RH, 2002, FASEB J, V16-
dc.description.citedreferenceHarris AL, 2002, NAT REV CANCER, V2, P38, DOI 10.1038/nrc704-
dc.description.citedreferenceBruick RK, 2001, SCIENCE, V294, P1337-
dc.description.citedreferenceSowter HM, 2001, CANCER RES, V61, P6669-
dc.description.citedreferenceYang XH, 2001, CANCER RES, V61, P5284-
dc.description.citedreferenceIvan M, 2001, SCIENCE, V292, P464-
dc.description.citedreferenceOdintsova E, 2000, CURR BIOL, V10, P1009-
dc.description.citedreferenceBruick RK, 2000, P NATL ACAD SCI USA, V97, P9082-
dc.description.citedreferenceMaxwell PH, 1999, NATURE, V399, P271-
dc.description.citedreferenceCarmeliet P, 1998, NATURE, V394, P485-
dc.description.citedreferenceDONG JT, 1995, SCIENCE, V268, P884-
dc.description.citedreferenceSEIZINGER BR, 1988, NATURE, V332, P268-
dc.description.tc2-
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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