Publications
Detailed Information
Genetic variants A1826H and D2937Y in GAG-beta domain of versican influence susceptibility to intestinal-type gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ju, Hyoungseok | - |
dc.contributor.author | Lim, Byungho | - |
dc.contributor.author | Kim, Minjin | - |
dc.contributor.author | Noh, Seung-Moo | - |
dc.contributor.author | Yu, Hang-Jong | - |
dc.contributor.author | Kim, Yong Sung | - |
dc.contributor.author | Ihm, Chunhwa | - |
dc.contributor.author | Kang, Changwon | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.contributor.author | Choi, Bo Youl | - |
dc.contributor.author | Han, Dong Soo | - |
dc.date.accessioned | 2012-05-31T06:34:41Z | - |
dc.date.available | 2012-05-31T06:34:41Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY; Vol.136 2; 195-201 | ko_KR |
dc.identifier.issn | 0171-5216 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76690 | - |
dc.description.abstract | Versican regulates adhesion, migration, proliferation, and survival of cells, and plays an important role in cancer development. A case-control association study was performed to test genetic association of versican polymorphisms with susceptibility to gastric cancer. In this study, 1,101 unrelated Korean subjects including 612 gastric cancer patients and 489 healthy controls were genotyped for all 21 exonic polymorphisms in the versican gene (VCAN) encoding amino acid changes in versican. Cancer susceptibility associations with the polymorphisms were assessed using multivariate logistic regression analysis with adjustment for age and gender and with control for multiple testing. Two amino acid changes in GAG-beta domain of versican encoded by two almost fully correlated (r (2) = 0.97) nonsynonymous single-nucleotide polymorphisms in VCAN were associated with gastric cancer. The association was evident in intestinal-type but not in diffuse-type gastric cancer. The minor-allele homozygote of rs188703 (G > A, R1826H) or rs160277 (G > T, D2937Y) was significantly associated with a twofold decreased susceptibility to intestinal-type gastric cancer when compared with the other genotypes (adjusted odds ratio = 0.52 or 0.51, P = 0.0098 or 0.0087, respectively). The intestinal-type gastric cancer susceptibility is associated with two amino acid changes of versican in the GAG-beta domain, which is critical for enhancement of cell proliferation and activation of EGFR signal pathway by versican, and changes from the major to minor alleles may impair the function to decrease susceptibility to cancer. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.subject | CSPG2 | ko_KR |
dc.subject | Genetic association | ko_KR |
dc.subject | Versican | ko_KR |
dc.subject | SNP | ko_KR |
dc.subject | Intestinal-type gastric cancer | ko_KR |
dc.title | Genetic variants A1826H and D2937Y in GAG-beta domain of versican influence susceptibility to intestinal-type gastric cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 주형석 | - |
dc.contributor.AlternativeAuthor | 임병호 | - |
dc.contributor.AlternativeAuthor | 김민진 | - |
dc.contributor.AlternativeAuthor | 노승무 | - |
dc.contributor.AlternativeAuthor | 한동수 | - |
dc.contributor.AlternativeAuthor | 유항종 | - |
dc.contributor.AlternativeAuthor | 최보율 | - |
dc.contributor.AlternativeAuthor | 김용성 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.contributor.AlternativeAuthor | 임춘화 | - |
dc.contributor.AlternativeAuthor | 강창원 | - |
dc.identifier.doi | 10.1007/s00432-009-0647-8 | - |
dc.citation.journaltitle | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | - |
dc.description.citedreference | Menashe I, 2008, BMC GENET, V9, DOI 10.1186/1471-2156-9-36 | - |
dc.description.citedreference | Theocharis AD, 2008, CONNECT TISSUE RES, V49, P230, DOI 10.1080/03008200802147571 | - |
dc.description.citedreference | Kim S, 2007, MOL CELLS, V24, P200 | - |
dc.description.citedreference | LaPierre DP, 2007, CANCER RES, V67, P4742, DOI 10.1158/0008-5472.CAN-06-3610 | - |
dc.description.citedreference | Yee AJ, 2007, BREAST CANCER RES, V9, DOI 10.1186/bcr1751 | - |
dc.description.citedreference | Sheng W, 2006, MOL BIOL CELL, V17, P2009, DOI 10.1091/mbc.E05-10-0951 | - |
dc.description.citedreference | Sheng W, 2005, MOL BIOL CELL, V16, P1330 | - |
dc.description.citedreference | Wu YJ, 2005, MATRIX BIOL, V24, P3, DOI 10.1016/j.matbio.2004.11.007 | - |
dc.description.citedreference | Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457 | - |
dc.description.citedreference | Wight TN, 2004, CIRC RES, V94, P1158, DOI 10.1161/01.RES.0000126921.29919.51 | - |
dc.description.citedreference | Zheng PS, 2004, FASEB J, V18, P754, DOI 10.1096/fj.03-0545fje | - |
dc.description.citedreference | Cattaruzza S, 2004, FASEB J, V18, P779, DOI 10.1096/fj.03-0660fje | - |
dc.description.citedreference | Stephens M, 2003, AM J HUM GENET, V73, P1162 | - |
dc.description.citedreference | Boussioutas A, 2003, CANCER RES, V63, P2569 | - |
dc.description.citedreference | Wight TN, 2002, CURR OPIN CELL BIOL, V14, P617, DOI 10.1016/S0955-0674(02)00375-7 | - |
dc.description.citedreference | Ramensky V, 2002, NUCLEIC ACIDS RES, V30, P3894 | - |
dc.description.citedreference | Ricciardelli C, 2002, CLIN CANCER RES, V8, P1054 | - |
dc.description.citedreference | Touab M, 2002, AM J PATHOL, V160, P549 | - |
dc.description.citedreference | Hippo Y, 2002, CANCER RES, V62, P233 | - |
dc.description.citedreference | Lemire JM, 2002, J CELL PHYSIOL, V190, P38 | - |
dc.description.citedreference | Stephens M, 2001, AM J HUM GENET, V68, P978 | - |
dc.description.citedreference | Sakko AJ, 2001, CANCER RES, V61, P926 | - |
dc.description.citedreference | SERRANO M, 2000, EMBO REP, V1, P115 | - |
dc.description.citedreference | Brown LF, 1999, CLIN CANCER RES, V5, P1041 | - |
dc.description.citedreference | Evanko SP, 1999, ARTERIOSCL THROM VAS, V19, P1004 | - |
dc.description.citedreference | Yang BL, 1999, J CELL BIOCHEM, V72, P210 | - |
dc.description.citedreference | Zhang Y, 1998, J BIOL CHEM, V273, P21342 | - |
dc.description.citedreference | Schmalfeldt M, 1998, J BIOL CHEM, V273, P15758 | - |
dc.description.citedreference | Paulus W, 1996, J NEUROPATH EXP NEUR, V55, P528 | - |
dc.description.citedreference | LANDOLT RM, 1995, DEVELOPMENT, V121, P2303 | - |
dc.description.citedreference | DOURSZIMMERMANN MT, 1994, J BIOL CHEM, V269, P32992 | - |
dc.description.tc | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.