Publications
Detailed Information
Interaction between the mouse homologue of CD99 and its ligand PILR as a mechanism of T cell receptor-independent thymocyte apoptosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hyo Jin | - |
dc.contributor.author | Ban, Young Larn | - |
dc.contributor.author | Byun, Dahye | - |
dc.contributor.author | Park, Seong Hoe | - |
dc.contributor.author | Jung, Kyeong Cheon | - |
dc.date.accessioned | 2012-05-31T07:00:26Z | - |
dc.date.available | 2012-05-31T07:00:26Z | - |
dc.date.issued | 2010-05-31 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.42 5; 353-365 | ko_KR |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76696 | - |
dc.description.abstract | Here, we show that the interaction between two membrane proteins, the mouse homologue of CD99 (designated D4) and its ligand, paired immunoglobulin-like type 2 receptor (PILR), is one of the major mechanisms of thymocyte apoptosis. Using the polymeric fusion protein of PILR and IgG1 (PILR-Ig), we demonstrated that D4 ligation in the absence of T cell receptor (TCR) engagement leads to the induction of apoptosis, mainly at the double-positive stage of thymocytes. This was further confirmed by a blocking study in which blocking the interaction between D4 and PILR by soluble D4 protein led to reduced apoptosis in the fetal thymic organ culture with wild type and TCR alpha(-/-) mice. Furthermore, the dissection of intracellular signaling pathway demonstrated that D4 cross-linking led to caspase activation without any change in mitochondrial membrane potential. Based on these data, we propose a mechanism for thymocyte depletion in which the interaction between D4 and PILR delivers an active signal. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | ko_KR |
dc.subject | apoptosis | ko_KR |
dc.subject | thymocyte | ko_KR |
dc.subject | T cell receptor | ko_KR |
dc.subject | CD99 antigen, mouse | ko_KR |
dc.subject | PILR protein, mouse | ko_KR |
dc.title | Interaction between the mouse homologue of CD99 and its ligand PILR as a mechanism of T cell receptor-independent thymocyte apoptosis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박효진 | - |
dc.contributor.AlternativeAuthor | 반영란 | - |
dc.contributor.AlternativeAuthor | 변다혜 | - |
dc.contributor.AlternativeAuthor | 박성회 | - |
dc.contributor.AlternativeAuthor | 정경천 | - |
dc.identifier.doi | 10.3858/emm.2010.42.5.037 | - |
dc.citation.journaltitle | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.description.citedreference | Kim K, 2009, EXP MOL MED, V41, P429, DOI 10.3858/emm.2009.41.6.048 | - |
dc.description.citedreference | Grebe KM, 2004, P NATL ACAD SCI USA, V101, P10410, DOI 10.1073/pnas.0402079101 | - |
dc.description.citedreference | Jung KC, 2004, J IMMUNOL, V172, P795 | - |
dc.description.citedreference | Minter LM, 2003, SEMIN IMMUNOL, V15, P135, DOI 10.1016/S1044-5323(03)00029-0 | - |
dc.description.citedreference | Salmena L, 2003, GENE DEV, V17, P883, DOI 10.1101/gad.1063703 | - |
dc.description.citedreference | Marchetti MC, 2003, BLOOD, V101, P585, DOI 10.1182/blood-2002-06-1779 | - |
dc.description.citedreference | Rathmell JC, 2002, NAT IMMUNOL, V3, P932, DOI 10.1038/ni834 | - |
dc.description.citedreference | Brewer JA, 2002, J IMMUNOL, V169, P1837 | - |
dc.description.citedreference | Matsuki Y, 2002, SCAND J IMMUNOL, V56, P174 | - |
dc.description.citedreference | Arthos J, 2002, J BIOL CHEM, V277, P11456, DOI 10.1074/jbc.M111191200 | - |
dc.description.citedreference | Krammer PH, 2000, NATURE, V407, P789 | - |
dc.description.citedreference | Ashwell JD, 2000, ANNU REV IMMUNOL, V18, P309 | - |
dc.description.citedreference | Bouillet P, 1999, SCIENCE, V286, P1735 | - |
dc.description.citedreference | Vacchio MS, 1999, J IMMUNOL, V163, P1327 | - |
dc.description.citedreference | Wallach D, 1999, ANNU REV IMMUNOL, V17, P331 | - |
dc.description.citedreference | Rathmell JC, 1999, ANNU REV IMMUNOL, V17, P781 | - |
dc.description.citedreference | Ashkenazi A, 1998, SCIENCE, V281, P1305 | - |
dc.description.citedreference | Green DR, 1998, SCIENCE, V281, P1309 | - |
dc.description.citedreference | Luo X, 1998, CELL, V94, P481 | - |
dc.description.citedreference | Li HL, 1998, CELL, V94, P491 | - |
dc.description.citedreference | Kuwana T, 1998, J BIOL CHEM, V273, P16589 | - |
dc.description.citedreference | Cresswell P, 1998, SCIENCE, V280, P394 | - |
dc.description.citedreference | Scaffidi C, 1998, EMBO J, V17, P1675 | - |
dc.description.citedreference | Hirata H, 1998, J EXP MED, V187, P587 | - |
dc.description.citedreference | CHOI EY, 1998, J IMMUNOL, V161, P749 | - |
dc.description.citedreference | Punt JA, 1997, J EXP MED, V186, P1911 | - |
dc.description.citedreference | Lesage S, 1997, J IMMUNOL, V159, P4762 | - |
dc.description.citedreference | vonFreedenJeffry U, 1997, IMMUNITY, V7, P147 | - |
dc.description.citedreference | Akashi K, 1997, CELL, V89, P1033 | - |
dc.description.citedreference | Bernard G, 1997, J IMMUNOL, V158, P2543 | - |
dc.description.citedreference | KROEMER G, 1995, FASEB J, V9, P1277 | - |
dc.description.citedreference | ZAMZAMI N, 1995, J EXP MED, V182, P367 | - |
dc.description.citedreference | ZAMZAMI N, 1995, J EXP MED, V181, P1661 | - |
dc.description.citedreference | VONFREEDENJEFFRY U, 1995, J EXP MED, V181, P1519 | - |
dc.description.citedreference | BERNARD G, 1995, J IMMUNOL, V154, P26 | - |
dc.description.citedreference | LINETTE GP, 1994, IMMUNITY, V1, P197 | - |
dc.description.citedreference | STRASSER A, 1994, P NATL ACAD SCI USA, V91, P1376 | - |
dc.description.citedreference | CRUMP AL, 1993, P NATL ACAD SCI USA, V90, P10739 | - |
dc.description.citedreference | CHAN SH, 1993, CELL, V73, P225 | - |
dc.description.citedreference | HUESMANN M, 1991, CELL, V66, P533 | - |
dc.description.citedreference | FRANKEL WN, 1991, NATURE, V349, P526 | - |
dc.description.citedreference | COHEN JJ, 1991, ADV IMMUNOL, V50, P55 | - |
dc.description.citedreference | JENKINSON EJ, 1990, EUR J IMMUNOL, V20, P2517 | - |
dc.description.citedreference | JENKINSON EJ, 1982, EUR J IMMUNOL, V12, P583 | - |
dc.description.tc | 0 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.