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Interaction between the mouse homologue of CD99 and its ligand PILR as a mechanism of T cell receptor-independent thymocyte apoptosis

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dc.contributor.authorPark, Hyo Jin-
dc.contributor.authorBan, Young Larn-
dc.contributor.authorByun, Dahye-
dc.contributor.authorPark, Seong Hoe-
dc.contributor.authorJung, Kyeong Cheon-
dc.date.accessioned2012-05-31T07:00:26Z-
dc.date.available2012-05-31T07:00:26Z-
dc.date.issued2010-05-31-
dc.identifier.citationEXPERIMENTAL AND MOLECULAR MEDICINE; Vol.42 5; 353-365ko_KR
dc.identifier.issn1226-3613-
dc.identifier.urihttps://hdl.handle.net/10371/76696-
dc.description.abstractHere, we show that the interaction between two membrane proteins, the mouse homologue of CD99 (designated D4) and its ligand, paired immunoglobulin-like type 2 receptor (PILR), is one of the major mechanisms of thymocyte apoptosis. Using the polymeric fusion protein of PILR and IgG1 (PILR-Ig), we demonstrated that D4 ligation in the absence of T cell receptor (TCR) engagement leads to the induction of apoptosis, mainly at the double-positive stage of thymocytes. This was further confirmed by a blocking study in which blocking the interaction between D4 and PILR by soluble D4 protein led to reduced apoptosis in the fetal thymic organ culture with wild type and TCR alpha(-/-) mice. Furthermore, the dissection of intracellular signaling pathway demonstrated that D4 cross-linking led to caspase activation without any change in mitochondrial membrane potential. Based on these data, we propose a mechanism for thymocyte depletion in which the interaction between D4 and PILR delivers an active signal.ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGYko_KR
dc.subjectapoptosisko_KR
dc.subjectthymocyteko_KR
dc.subjectT cell receptorko_KR
dc.subjectCD99 antigen, mouseko_KR
dc.subjectPILR protein, mouseko_KR
dc.titleInteraction between the mouse homologue of CD99 and its ligand PILR as a mechanism of T cell receptor-independent thymocyte apoptosisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박효진-
dc.contributor.AlternativeAuthor반영란-
dc.contributor.AlternativeAuthor변다혜-
dc.contributor.AlternativeAuthor박성회-
dc.contributor.AlternativeAuthor정경천-
dc.identifier.doi10.3858/emm.2010.42.5.037-
dc.citation.journaltitleEXPERIMENTAL AND MOLECULAR MEDICINE-
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