Publications
Detailed Information
Cessation of Gonadotropin-Releasing Hormone Antagonist on Triggering Day: An Alternative Method for Flexible Multiple-Dose Protocol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Hye Jin | - |
dc.contributor.author | Lee, Jung Ryeol | - |
dc.contributor.author | Jee, Byung Chul | - |
dc.contributor.author | Suh, Chang Suk | - |
dc.contributor.author | Kim, Seok Hyun | - |
dc.date.accessioned | 2012-06-04T04:51:01Z | - |
dc.date.available | 2012-06-04T04:51:01Z | - |
dc.date.issued | 2009-04 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.24 2; 262-268 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76774 | - |
dc.description.abstract | This study was performed to analyze retrospectively outcomes of stimulated in vitro fertilization (IVF) cycles where the gonadotropin-releasing hormone (GnRH) antagonist was omitted on ovulation triggering day. A total of 92 consecutive IVF cycles were included in 65 women who are undergoing ovarian stimulation with recombinant FSH. A GnRH antagonist, cetrorelix 0.25 mg/day, was started when leading follicle reached 14 mm in diameter until the day of hCG administration (Group A, 66 cycles) or until the day before hCG administration (Group B, 26 cycles). The duration of ovarian stimulation, total dose of gonadotropins, serum estradiol levels on hCG administration day, and the number of oocytes retrieved were not significantly different between the two groups. The total dose of GnRH antagonist was significantly lower in Group B compared to Group A (2.7 +/- 0.8 vs. 3.2 +/- 0.9 ampoules). There was no premature luteinization in the subjects. The proportion of mature oocytes (71.4% vs. 61.7%) and fertilization rate of mature (86.3 +/- 19.7% vs. 71.8 +/- 31.7%) was significantly higher in Group B. There were no significant differences in embryo quality and clinical pregnancy rates. Our results suggest that cessation of the GnRH antagonist on the day of hCG administration during a flexible multiple-dose protocol could reduce the total dose of GnRH antagonist without compromising IVF results. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | GnRH Antagonist | ko_KR |
dc.subject | Ovulation Induction | ko_KR |
dc.subject | Cetrorelix | ko_KR |
dc.subject | Fertilization | ko_KR |
dc.subject | hCG Administration | ko_KR |
dc.subject | Oocyte Maturation | ko_KR |
dc.title | Cessation of Gonadotropin-Releasing Hormone Antagonist on Triggering Day: An Alternative Method for Flexible Multiple-Dose Protocol | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 장혜진 | - |
dc.contributor.AlternativeAuthor | 이정렬 | - |
dc.contributor.AlternativeAuthor | 지병철 | - |
dc.contributor.AlternativeAuthor | 서창석 | - |
dc.contributor.AlternativeAuthor | 김석현 | - |
dc.identifier.doi | 10.3346/jkms.2009.24.2.262 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.description.citedreference | Lee JR, 2007, FERTIL STERIL, V88, P1344, DOI 10.1016/j.fertnstert.2007.01.013 | - |
dc.description.citedreference | Frankfurter D, 2007, FERTIL STERIL, V88, P1442, DOI 10.1016/j.fertnstert.2007.01.022 | - |
dc.description.citedreference | Huirne JA, 2007, HUM REPROD, V22, P2805, DOI 10.1093/humrep/dem270 | - |
dc.description.citedreference | Venetisi CA, 2007, HUM REPROD UPDATE, V13, P343, DOI 10.1093/humupd/dmm007 | - |
dc.description.citedreference | Ikemoto T, 2007, J MOL ENDOCRINOL, V38, P289, DOI 10.1677/JME-06-0010 | - |
dc.description.citedreference | Allegra A, 2007, HUM REPROD, V22, P101, DOI 10.1093/humrep/del337 | - |
dc.description.citedreference | Kolibianakis EM, 2006, HUM REPROD UPDATE, V12, P651, DOI 10.1093/humupd/dml038 | - |
dc.description.citedreference | Chen HJ, 2006, J ASSIST REPROD GEN, V23, P289, DOI 10.1007/s10815-006-9054-0 | - |
dc.description.citedreference | Griesinger G, 2006, FERTIL STERIL, V85, P791, DOI 10.1016/j.fertnstert.2005.08.048 | - |
dc.description.citedreference | Olivennes F, 2006, CLIN OBSTET GYNECOL, V49, P12 | - |
dc.description.citedreference | Kolibianakis EM, 2006, HUM REPROD, V21, P352, DOI 10.1093/humrep/dei348 | - |
dc.description.citedreference | ALINANY HG, 2006, COCHRANE DB SYST REV, V3, P1750 | - |
dc.description.citedreference | Simon C, 2005, HUM REPROD, V20, P3318 | - |
dc.description.citedreference | Messinis IE, 2005, HUM REPROD, V20, P3192, DOI 10.1093/humrep/dei210 | - |
dc.description.citedreference | Griesinger G, 2005, HUM REPROD, V20, P2373, DOI 10.1093/humrep/dei086 | - |
dc.description.citedreference | Fauser BCJM, 2005, FERTIL STERIL, V83, P1607, DOI 10.1016/j.fertnstert.2005.02.01 | - |
dc.description.citedreference | Al-Inany H, 2005, GYNECOL ENDOCRINOL, V20, P161, DOI 10.1080/09513590400027232 | - |
dc.description.citedreference | Huirne JAF, 2005, HUM REPROD, V20, P359, DOI 10.1093/humrep/deh601 | - |
dc.description.citedreference | Saadat P, 2004, FERTIL STERIL, V82, P167, DOI 10.1016/j.fertnstert.2003.11.050 | - |
dc.description.citedreference | Kolibianakis EM, 2003, J CLIN ENDOCR METAB, V88, P5632, DOI 10.1210/jc.2003-030805 | - |
dc.description.citedreference | ROULIER R, 2003, REPROD BIOMED ONLINE, V7, P185 | - |
dc.description.citedreference | Al-Inany H, 2002, HUM REPROD, V17, P874 | - |
dc.description.citedreference | Grundker C, 2002, J CLIN ENDOCR METAB, V87, P1427 | - |
dc.description.citedreference | Hernandez ER, 2000, HUM REPROD, V15, P1211 | - |
dc.description.citedreference | Olivennes F, 2000, FERTIL STERIL, V73, P314 | - |
dc.description.citedreference | Ortmann O, 1999, HUM REPROD, V14, P194 | - |
dc.description.citedreference | Kol S, 1999, HUM REPROD, V14, P2242 | - |
dc.description.citedreference | Mannaerts B, 1998, HUM REPROD, V13, P3023 | - |
dc.description.citedreference | PENG C, 1994, ENDOCRINOLOGY, V135, P1740 | - |
dc.description.citedreference | DIEDRICH K, 1994, HUM REPROD, V9, P788 | - |
dc.description.citedreference | HILLIER SG, 1994, HUM REPROD, V9, P188 | - |
dc.description.citedreference | BROWN JB, 1978, AUSTR NZ J OBSTETRIC, V18, P46 | - |
dc.description.tc | 1 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.