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Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis

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dc.contributor.authorLee, Hyun Soon-
dc.contributor.authorSong, Chi Young-
dc.date.accessioned2012-06-04T08:05:13Z-
dc.date.available2012-06-04T08:05:13Z-
dc.date.issued2009-
dc.identifier.citationAMERICAN JOURNAL OF NEPHROLOGY; Vol.29 1; 62-70ko_KR
dc.identifier.issn0250-8095-
dc.identifier.urihttps://hdl.handle.net/10371/76802-
dc.description.abstractGlomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed. Copyright (C) 2008 S. Karger AG, Baselko_KR
dc.language.isoenko_KR
dc.publisherKARGERko_KR
dc.subjectAngiotensin IIko_KR
dc.subjectTGF-beta signalingko_KR
dc.subjectReactive aldehydesko_KR
dc.subjectNADPH oxidaseko_KR
dc.subjectDyslipidemiako_KR
dc.subjectMesangial matrixko_KR
dc.titleOxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이현순-
dc.contributor.AlternativeAuthor송지영-
dc.identifier.doi10.1159/000151277-
dc.citation.journaltitleAMERICAN JOURNAL OF NEPHROLOGY-
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