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Patients with an asymptomatic short cervix (<= 15 mm) have a high rate of subclinical intraamniotic inflammation: implications for patient counseling

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dc.contributor.authorVaisbuch, Edi-
dc.contributor.authorHassan, Sonia S.-
dc.contributor.authorMazaki-Tovi, Shali-
dc.contributor.authorNhan-Chang, Chia-Ling-
dc.contributor.authorChaiworapongsa, Tinnakorn-
dc.contributor.authorYeo, Lami-
dc.contributor.authorYoon, Bo Hyun-
dc.contributor.authorRomero, Roberto-
dc.contributor.authorMittal, Pooja-
dc.contributor.authorDong, Zhong-
dc.contributor.authorKusanovic, Juan Pedro-
dc.date.accessioned2012-06-05T00:34:35Z-
dc.date.available2012-06-05T00:34:35Z-
dc.date.issued2010-05-
dc.identifier.citationAMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY; Vol.202 5; -ko_KR
dc.identifier.issn0002-9378-
dc.identifier.urihttps://hdl.handle.net/10371/76816-
dc.description.abstractOBJECTIVE: The objective of the study was to determine the frequency and clinical significance of intraamniotic inflammation in asymptomatic women with a sonographic short cervix (SCX) in the midtrimester. STUDY DESIGN: This cohort study included 47 asymptomatic women (14-24 weeks) with an SCX (<= 15 mm) who underwent amniocentesis. Women with multiple gestation, cerclage, or cervical dilatation greater than 2 cm were excluded. Intraamniotic inflammation was defined as an elevated amniotic fluid (AF) matrix metalloproteinase-8 concentration (>23 ng/mL). RESULTS: (1) intraamniotic infection was found in 4.3% of patients; (2) among patients with a negative AF culture, the prevalence of intraamniotic inflammation was 22.2%; and (3) patients with a negative AF culture, but with intraamniotic inflammation, had a higher rate of delivery within 7 days (40% vs 5.7%; P = .016) and a shorter median diagnosis-to-delivery interval than those without intraamniotic inflammation (18 vs 42 days; P = .01). CONCLUSION: Twenty-two percent of patients with a midtrimester SCX have intraamniotic inflammation. The risk of preterm delivery within 7 days for these patients is 40%.ko_KR
dc.language.isoenko_KR
dc.publisherMOSBY-ELSEVIERko_KR
dc.subjectcervical lengthko_KR
dc.subjectmatrix metalloproteinase-8ko_KR
dc.subjectMMP-8ko_KR
dc.subjectintraamniotic inflammationko_KR
dc.subjectpregnancyko_KR
dc.subjectpreterm deliveryko_KR
dc.subjectprematurityko_KR
dc.titlePatients with an asymptomatic short cervix (<= 15 mm) have a high rate of subclinical intraamniotic inflammation: implications for patient counselingko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor윤보현-
dc.identifier.doi10.1016/j.ajog.2010.02.007-
dc.citation.journaltitleAMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY-
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