S-Space College of Medicine/School of Medicine (의과대학/대학원) Obstetrics & Gynecology (산부인과전공) Journal Papers (저널논문_산부인과학전공)
Estrogen receptor beta gene+1730 G/A polymorphism in women with polycystic ovary syndrome
- Kim, Jin Ju; Choi, Young Min; Choung, Seon Ha; Yoon, Sang Ho; Moon, Shin Yong; Lee, Gyoung Hoon
- Issue Date
- ELSEVIER SCIENCE INC
- FERTILITY AND STERILITY; Vol.93 6; 1942-1947
- Objective: To investigate whether the +1730 G/A polymorphism in the estrogen receptor (ER)-beta gene is associated with susceptibility to polycystic ovary syndrome (PCOS). Design: Case control study. Setting: University Department of Obstetrics and Gynecology. Patient(s): Women with (n = 138) or without (n = 290) PCOS. Intervention(s): Genotyping was performed by polymerase chain reaction restriction fragment-length polymorphism analysis. Main Outcome Measure(s): Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene. Result(s): There was a significant difference in the genotype distribution between the patients with PCOS and controls (non-GO rates were 22.1% for patients with PCOS and 36.6% for controls). There was also a significant difference in the G and A allele frequencies between these two groups (11.7% in patients vs. 19.1% in controls with A allele). But in patients with PCOS there were no significant differences in the serum levels of hormones, biochemical variables, or ovarian morphology between GG and non-GG genotypes. Conclusion(s): The ER-beta gene +1730 G/A polymorphism may be associated with pathophysiologic aberrancies involved in PCOS. (Fertil Steril (R) 2010;93:1942-7. (C)2010 by American Society for Reproductive Medicine.)
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