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Preclinical Analysis of Irreversible Electroporation on Rat Liver Tissues Using a Microfabricated Electroporator

Cited 12 time in Web of Science Cited 11 time in Scopus
Authors
Choi, Youn-Suk; Kim, Hong-Bae; Chung, Junho; Kim, Hyung-Sik; Park, Je-Kyun; Yi, Jeong-Han
Issue Date
2010-12
Publisher
MARY ANN LIEBERT INC
Citation
TISSUE ENGINEERING PART C-METHODS; Vol.16 6; 1245-1253
Abstract
A microfabricated electroporator (MFE) for the irreversible electroporation (IRE) of tissues has been developed by miniaturizing a clinical electroporator with a two-needle array while keeping the same electric field strength distribution. Since IRE was brought to special attention as one of the local tissue ablation techniques to treat tumors, many preclinical studies have been conducted to investigate the efficacy of IRE on animal tissues. However, some technical difficulties have been frequently encountered due to the macroscale dimension of clinical electroporators, particularly in experiments on small animal models such as the mouse or rat. Here, the MFE was proposed to solve the associated problems, resulting in time-and cost-effective experimental procedures. With the developed MFE, the effect of IRE on rat liver tissues was analyzed with time by immunohistological stainings and electrical measurement, and the experimental results were compared with those operated with the corresponding real-scale clinical electroporator.
ISSN
1937-3384
Language
English
URI
http://hdl.handle.net/10371/76838
DOI
https://doi.org/10.1089/ten.tec.2009.0803
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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