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Gq protein mediates UVB-induced cyclooxygenase-2 expression by stimulating HB-EGF secretion from HaCaT human keratinocytes
DC Field | Value | Language |
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dc.contributor.author | Seo, MiRan | - |
dc.contributor.author | Juhnn, Yong-Sung | - |
dc.date.accessioned | 2012-06-05T05:49:58Z | - |
dc.date.available | 2012-06-05T05:49:58Z | - |
dc.date.issued | 2010-03-05 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Vol.393 2; 190-195 | ko_KR |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/76850 | - |
dc.description.abstract | Ultraviolet (UV) radiation induces cyclooxygenase-2 expression to produce cellular responses including aging and carcinogenesis in skin. We hypothesised that heterotrimeric G proteins mediate UV-induced COX-2 expression by stimulating secretion of soluble HB-EGF (sHB-EGF). In this study, we aimed to elucidate the role and underlying mechanism of the a subunit of Gq protein (G alpha q) in UVB-induced HB-EGF secretion and COX-2 induction. We found that expression of constitutively active G alpha q (G alpha qQL) augmented UVB-induced HB-EGF secretion. which was abolished by knockdown of G alpha q with shRNA in HaCaT human keratinocytes. G alpha q was found to mediate the UVB-induced HB-EGF secretion by sequential activation of phospholipase C (PLC), protein kinase C delta (PKC delta), and matrix metaloprotease-2 (MMP-2). Moreover, G alpha qQL mediated UVB-induced COX-2 expression in an HH-EGF-, EGFR-, and p38-dependent manner. From these results, we concluded that G alpha q mediates UV-induced COX-2 expression through activation of EGFR by HB-EGF, of which ectodomain shedding was stimulated through sequential activation of PLC, PKC delta and MMP-2 in HaCaT cells. (C) 2010 Elsevier Inc. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | ko_KR |
dc.subject | Gαq | ko_KR |
dc.subject | Keratinocytes | ko_KR |
dc.subject | UVB | ko_KR |
dc.subject | HB-EGF | ko_KR |
dc.subject | COX-2 | ko_KR |
dc.title | Gq protein mediates UVB-induced cyclooxygenase-2 expression by stimulating HB-EGF secretion from HaCaT human keratinocytes | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 서미란 | - |
dc.contributor.AlternativeAuthor | 전용성 | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.01.085 | - |
dc.citation.journaltitle | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
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