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Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria

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dc.contributor.authorLee, Jung Eun-
dc.contributor.authorPark, Hansoo-
dc.contributor.authorJu, Young Seok-
dc.contributor.authorKwak, Minhye-
dc.contributor.authorOh, Ha Young-
dc.contributor.authorSeo, Jeong-Sun-
dc.contributor.authorKim, Jong-Il-
dc.date.accessioned2012-06-05T06:10:05Z-
dc.date.available2012-06-05T06:10:05Z-
dc.date.issued2009-04-30-
dc.identifier.citationEXPERIMENTAL AND MOLECULAR MEDICINE; Vol.41 4; 253-258ko_KR
dc.identifier.issn1226-3613-
dc.identifier.urihttps://hdl.handle.net/10371/76855-
dc.description.abstractIt has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondriall DNA (mtDNA) copy number and microalbuminuria in a cross-sectional community-based study. We measured peripheral blood mtDNA copy number in 694 adults without chronic kidney disease by a real-time PCR method. The overall prevalence of microalbuminuria (defined as an albumin creatinine ratio of 30 to 299 mg/g) was 4.5%. The prevalence of microalbuminuria decreased progressively from the lower to the upper quartiles of mtDNA copy number (6.9%, 5.7%, 2.9%, and 2.3% in quartiles 1, 2, 3, and 4, respectively, P = 0.017 for trend). Multiple logistic regression models showed that the quartile of mtDNA copy number was independently associated with the prevalence of microalbuminuria (P = 0.01 for trend). Compared with the lowest quartile, the highest quartile had an odds ratio of 0.22 for microalbuminuria (95% confidence interval, 0.05 to 0.87; P = 0.03). Higher mtDNA copy number was associated with the lower prevalence of microalbuminuria in a community-based population.ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGYko_KR
dc.subjectalbuminuriako_KR
dc.subjectoxidative phosphorylationko_KR
dc.subjectcardiovascular diseasesko_KR
dc.subjectDNA, mitochondrialko_KR
dc.subjectmitochondriako_KR
dc.titleHigher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuriako_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이정은-
dc.contributor.AlternativeAuthor박한수-
dc.contributor.AlternativeAuthor주영석-
dc.contributor.AlternativeAuthor곽민혜-
dc.contributor.AlternativeAuthor김종일-
dc.contributor.AlternativeAuthor오하영-
dc.contributor.AlternativeAuthor서정선-
dc.identifier.doi10.3858/emm.2009.41.4.028-
dc.citation.journaltitleEXPERIMENTAL AND MOLECULAR MEDICINE-
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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