Publications
Detailed Information
Exposure to volatile organic compounds and loss of pulmonary function in the elderly
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, H. I. | - |
dc.contributor.author | Hong, Y-C. | - |
dc.contributor.author | Cho, S-H. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Sohn, J. R. | - |
dc.contributor.author | Park, S-H. | - |
dc.contributor.author | Cheong, H-K. | - |
dc.contributor.author | Cho, M-H. | - |
dc.contributor.author | Kwon, M. | - |
dc.contributor.author | Kim, Y. H. | - |
dc.date.accessioned | 2012-06-07T07:02:53Z | - |
dc.date.available | 2012-06-07T07:02:53Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | EUROPEAN RESPIRATORY JOURNAL; Vol.36 6; 1270-1276 | ko_KR |
dc.identifier.issn | 0903-1936 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76875 | - |
dc.description.abstract | Volatile organic compounds (VOCs) are reported to cause adverse effects on pulmonary function in occupationally exposed workers. However, evidence is lacking on the effect in the general population. We hypothesised that VOCs impair pulmonary function through enhancing oxidative stress, especially in the elderly population. A longitudinal panel study of 154 elderly people was performed in South Korea. Repeated spirometric tests were performed up to eight times on different days for each subject. We also measured urinary concentrations of metabolites of the VOC and markers of oxidative stress (malondialdehyde and 8-oxo-2`-deoxyguanosine) on the same day of spirometric tests. A mixed linear regression model was used to evaluate the association among the VOC metabolites, oxidative stress markers and spirometric tests. We found that the urinary levels of hippuric acid and methylhippuric acid, which are metabolites of toluene and xylene, respectively, were significantly associated with reduction of forced expiratory volume in 1 s (FEV(1)), FEV(1)/forced vital capacity (FVC), and forced expiratory flow at 25-75% of FVC. We also found significant associations between the metabolites of VOCs and the markers of oxidative stress. In addition, the oxidative stress markers were associated with pulmonary function parameters. This study suggests that exposure to toluene and xylene exert a harmful effect on pulmonary function by exacerbating oxidative stress in elderly people. | ko_KR |
dc.description.sponsorship | This study was supported by the Ministry of Environment, South
Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | EUROPEAN RESPIRATORY SOC JOURNALS LTD | ko_KR |
dc.subject | Elderly | ko_KR |
dc.subject | pulmonary function | ko_KR |
dc.subject | volatile organic compounds | ko_KR |
dc.subject | oxidative stress | ko_KR |
dc.title | Exposure to volatile organic compounds and loss of pulmonary function in the elderly | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1183/09031936.00153509 | - |
dc.citation.journaltitle | EUROPEAN RESPIRATORY JOURNAL | - |
dc.description.citedreference | Medina-Ramon M, 2008, EPIDEMIOLOGY, V19, P672, DOI 10.1097/EDE.0b013e3181773476 | - |
dc.description.citedreference | Roder-Stolinski C, 2008, TOXICOL APPL PHARM, V231, P241, DOI 10.1016/j.taap.2008.04.010 | - |
dc.description.citedreference | Oftedal B, 2008, EPIDEMIOLOGY, V19, P129, DOI 10.1097/EDE.0b013e31815c0827 | - |
dc.description.citedreference | AKBARALY TN, 2008, BR J NUTR, V29, P1 | - |
dc.description.citedreference | Downs SH, 2007, NEW ENGL J MED, V357, P2338, DOI 10.1056/NEJMoa073625 | - |
dc.description.citedreference | Lippmann M, 2007, NEW ENGL J MED, V357, P2395 | - |
dc.description.citedreference | van der Toorn M, 2007, AM J PHYSIOL-LUNG C, V293, pL1156, DOI 10.1152/ajplung.00081.2007 | - |
dc.description.citedreference | Sircar K, 2007, OCCUP ENVIRON MED, V64, P461, DOI 10.1136/oem.2006.031419 | - |
dc.description.citedreference | Cakmak S, 2007, ENVIRON HEALTH PERSP, V115, P524, DOI 10.1289/ehp.9567 | - |
dc.description.citedreference | Elliott L, 2006, ENVIRON HEALTH PERSP, V114, P1210, DOI 10.1289/ehp.9019 | - |
dc.description.citedreference | Garcon G, 2006, TOXICOL IN VITRO, V20, P519, DOI 10.1016/j.tiv.2005.09.012 | - |
dc.description.citedreference | Kelly FJ, 2005, P NUTR SOC, V64, P510, DOI 10.1079/PNS2005457 | - |
dc.description.citedreference | Drost EM, 2005, THORAX, V60, P293, DOI 10.1136/thx.2004.027946 | - |
dc.description.citedreference | Kim YJ, 2005, REPROD TOXICOL, V19, P487, DOI 10.1016/j.reprotox.2004.10.007 | - |
dc.description.citedreference | Sexton K, 2004, ENVIRON SCI TECHNOL, V38, P423 | - |
dc.description.citedreference | Mannino DM, 2003, THORAX, V58, P388 | - |
dc.description.citedreference | Coleman CA, 2003, TOXICOL LETT, V142, P133 | - |
dc.description.citedreference | FISCHER P, 2003, EUR RESPIR J, V40, pS34 | - |
dc.description.citedreference | Zima T, 2001, J BIOMED SCI, V8, P59 | - |
dc.description.citedreference | SAHIN U, 2001, J BASIC CLIN PHYSL P, V12, P59 | - |
dc.description.citedreference | Talini D, 1998, OCCUP ENVIRON MED, V55, P786 | - |
dc.description.citedreference | Abbey DE, 1998, AM J RESP CRIT CARE, V158, P289 | - |
dc.description.citedreference | Wieslander G, 1997, ANN OCCUP HYG, V41, P155 | - |
dc.description.citedreference | AckermannLiebrich U, 1997, AM J RESP CRIT CARE, V155, P122 | - |
dc.description.citedreference | Hole DJ, 1996, BRIT MED J, V313, P711 | - |
dc.description.citedreference | ANTHONISEN NR, 1994, JAMA-J AM MED ASSOC, V272, P1497 | - |
dc.description.citedreference | STAMPFER MJ, 1993, NEW ENGL J MED, V328, P1444 | - |
dc.description.citedreference | RIMM EB, 1993, NEW ENGL J MED, V328, P1450 | - |
dc.description.citedreference | WILLIAM A, 1993, ANN NY ACAD SCI, V686, P12 | - |
dc.description.citedreference | WALLACE LA, 1991, TOXICOL IND HEALTH, V7, P203 | - |
dc.description.tc | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.