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Relationship between Environmental Phthalate Exposure and the Intelligence of School-Age Children
DC Field | Value | Language |
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dc.contributor.author | Cho, Soo-Churl | - |
dc.contributor.author | Bhang, Soo-Young | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Shin, Min-Sup | - |
dc.contributor.author | Kim, Jae-Won | - |
dc.contributor.author | Cho, In Hee | - |
dc.contributor.author | Kim, Hyo-Won | - |
dc.contributor.author | Yoo, Hee-Jung | - |
dc.contributor.author | Kim, Boong-Nyun | - |
dc.date.accessioned | 2012-06-08T01:06:25Z | - |
dc.date.available | 2012-06-08T01:06:25Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | ENVIRONMENTAL HEALTH PERSPECTIVES; Vol.118 7; 1027-1032 | ko_KR |
dc.identifier.issn | 0091-6765 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76904 | - |
dc.description.abstract | BACKGROUND: Concern over phthalates has emerged because of their potential toxicity to humans. OBJECTIVE: We investigated the relationship between the urinary concentrations of phthalate metabolites and children`s intellectual functioning. METHODS: This study enrolled 667 children at nine elementary schools in five South Korean cities. A cross-sectional examination of urine phthalate concentrations was performed, and scores on neuro-psychological tests were obtained from both the children and their mothers. RESULTS: We measured mono-2-ethylhexyl phthalate (MEHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), both metabolites of di(2-ethylhexyl)phthalate (DEHP), and mono-n-butyl phthalate (MBP), a metabolite of dibutyl phthalate (DBP), in urine samples. The geometric mean (ln) concentrations of MEHP, MEOHP, and MBP were 21.3 mu g/L [geometric SD (GSD) = 2.2 mu g/L; range, 0.5-445.4], 18.0 mu g/L (GSD = 2.4; range, 0.07-291.1), and 48.9 mu g/L (GSD = 2.2; range, 2.1-1645.5), respectively. After adjusting for demographic and developmental covariates, the Full Scale IQ and Verbal IQ scores were negatively associated with DEHP metabolites but not with DBP metabolites. We also found a significant negative relationship between the urine concentrations of the metabolites of DEHP and DBP and children`s vocabulary subscores. After controlling for maternal IQ, a significant inverse relationship between DEHP metabolites and vocabulary subscale score remained. Among boys, we found a negative association between increasing MEHP phthalate concentrations and the sum of DEHP metabolite concentrations and Wechsler Intelligence Scale for Children vocabulary score; however, among girls, we found no significant association between these variables. CONCLUSION: Controlling for maternal IQ and other covariates, the results show an inverse relationship between phthalate metabolites and IQ scores; however, given the limitations in cross-sectional epidemiology, prospective studies are needed to fully explore these associations. | ko_KR |
dc.description.sponsorship | This work was funded by the Eco-Technopia 21 project of Korea Institute of Environmental Science and Technology (091-081-059). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE | ko_KR |
dc.subject | children | ko_KR |
dc.subject | cognition | ko_KR |
dc.subject | sex | ko_KR |
dc.subject | phthalate | ko_KR |
dc.subject | mono-n-butyl phthalate (MBP) | ko_KR |
dc.subject | mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) | ko_KR |
dc.subject | mono-2-ethylhexyl phthalate (MEHP) | ko_KR |
dc.subject | IQ | ko_KR |
dc.subject | di(2-ethylhexyl)phthalate (DEHP) | ko_KR |
dc.subject | dibutyl phthalate (DBP) | ko_KR |
dc.title | Relationship between Environmental Phthalate Exposure and the Intelligence of School-Age Children | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 조수철 | - |
dc.contributor.AlternativeAuthor | 방수영 | - |
dc.contributor.AlternativeAuthor | 홍성철 | - |
dc.contributor.AlternativeAuthor | 신민섭 | - |
dc.contributor.AlternativeAuthor | 김붕년 | - |
dc.contributor.AlternativeAuthor | 김재원 | - |
dc.contributor.AlternativeAuthor | 유희정 | - |
dc.contributor.AlternativeAuthor | 조인희 | - |
dc.contributor.AlternativeAuthor | 김효원 | - |
dc.identifier.doi | 10.1289/ehp.0901376 | - |
dc.citation.journaltitle | ENVIRONMENTAL HEALTH PERSPECTIVES | - |
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