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Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women

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dc.contributor.authorLee, Ji-Young-
dc.contributor.authorPark, Ae Kyung-
dc.contributor.authorLee, Kyoung-Mu-
dc.contributor.authorPark, Sue K.-
dc.contributor.authorHan, Wonshik-
dc.contributor.authorYoo, Keun-Young-
dc.contributor.authorChanock, Stephen J.-
dc.contributor.authorKang, Daehee-
dc.contributor.authorRothman, Nathaniel-
dc.contributor.authorKim, Ho-
dc.contributor.authorNoh, Dong-Young-
dc.contributor.authorHan, Sohee-
dc.date.accessioned2012-06-08T06:40:50Z-
dc.date.available2012-06-08T06:40:50Z-
dc.date.issued2009-09-
dc.identifier.citationCARCINOGENESIS; Vol.30 9; 1528-1531ko_KR
dc.identifier.issn0143-3334-
dc.identifier.urihttps://hdl.handle.net/10371/76911-
dc.description.abstractObjectives: This study was conducted to investigate the role of common variation in innate immunity-related genes as susceptibility factors to breast cancer risk in Korean women. Methods: Total 1536 single-nucleotide polymorphisms (SNPs) in 203 genes were analyzed by Illumina GoldenGate assay in 209 cases and the same numbers of controls. Both SNP and gene-based tests were used to evaluate the association with breast cancer risk. The robustness of results was further evaluated with permutation method, false discovery rate and haplotype analyses. Results: Both SNP and gene-based analyses showed promising associations with breast cancer risk for 17 genes: OR10J3, FCER1A, NCF4, CNTNAP1, CTNNB1, KLKB1, ITGB2, ALOX12B, KLK2, IRAK3, KLK4, STAT6, NCF2, CCL1, C1QR1, MBP and NOS1. The most significant association with breast cancer risk was observed for the OR10J3 SNP (rs2494251, P-value = 1.2 x 10(-4)) and FCER1A SNP (rs7548864, P-value = 7.7 x 10(-4)). Gene-based permutation and false discovery rate P-values for OR10J3 SNP (rs2494251) with breast cancer risk were also significant (P = 4 x 10(-5) and 0.008, respectively). Haplotype analyses supported these findings that OR10J3 and FCER1A were most significantly associated with risk for breast cancer (P = 2 x 10(-4) and 0.004, respectively). Conclusion: This study suggests that common genetic variants in the OR10J3 and FCER1A be strongly associated with breast cancer risk among Korean women.ko_KR
dc.language.isoenko_KR
dc.publisherOXFORD UNIV PRESSko_KR
dc.titleCandidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean womenko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이지영-
dc.contributor.AlternativeAuthor박애경-
dc.contributor.AlternativeAuthor이경무-
dc.contributor.AlternativeAuthor박수경-
dc.contributor.AlternativeAuthor한소희-
dc.contributor.AlternativeAuthor한원식-
dc.contributor.AlternativeAuthor노동영-
dc.contributor.AlternativeAuthor유근영-
dc.contributor.AlternativeAuthor김호-
dc.contributor.AlternativeAuthor강대희-
dc.identifier.doi10.1093/carcin/bgp084-
dc.citation.journaltitleCARCINOGENESIS-
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