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Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji-Young | - |
dc.contributor.author | Park, Ae Kyung | - |
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Park, Sue K. | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Yoo, Keun-Young | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Kim, Ho | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Han, Sohee | - |
dc.date.accessioned | 2012-06-08T06:40:50Z | - |
dc.date.available | 2012-06-08T06:40:50Z | - |
dc.date.issued | 2009-09 | - |
dc.identifier.citation | CARCINOGENESIS; Vol.30 9; 1528-1531 | ko_KR |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76911 | - |
dc.description.abstract | Objectives: This study was conducted to investigate the role of common variation in innate immunity-related genes as susceptibility factors to breast cancer risk in Korean women. Methods: Total 1536 single-nucleotide polymorphisms (SNPs) in 203 genes were analyzed by Illumina GoldenGate assay in 209 cases and the same numbers of controls. Both SNP and gene-based tests were used to evaluate the association with breast cancer risk. The robustness of results was further evaluated with permutation method, false discovery rate and haplotype analyses. Results: Both SNP and gene-based analyses showed promising associations with breast cancer risk for 17 genes: OR10J3, FCER1A, NCF4, CNTNAP1, CTNNB1, KLKB1, ITGB2, ALOX12B, KLK2, IRAK3, KLK4, STAT6, NCF2, CCL1, C1QR1, MBP and NOS1. The most significant association with breast cancer risk was observed for the OR10J3 SNP (rs2494251, P-value = 1.2 x 10(-4)) and FCER1A SNP (rs7548864, P-value = 7.7 x 10(-4)). Gene-based permutation and false discovery rate P-values for OR10J3 SNP (rs2494251) with breast cancer risk were also significant (P = 4 x 10(-5) and 0.008, respectively). Haplotype analyses supported these findings that OR10J3 and FCER1A were most significantly associated with risk for breast cancer (P = 2 x 10(-4) and 0.004, respectively). Conclusion: This study suggests that common genetic variants in the OR10J3 and FCER1A be strongly associated with breast cancer risk among Korean women. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | OXFORD UNIV PRESS | ko_KR |
dc.title | Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이지영 | - |
dc.contributor.AlternativeAuthor | 박애경 | - |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 박수경 | - |
dc.contributor.AlternativeAuthor | 한소희 | - |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.contributor.AlternativeAuthor | 유근영 | - |
dc.contributor.AlternativeAuthor | 김호 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.identifier.doi | 10.1093/carcin/bgp084 | - |
dc.citation.journaltitle | CARCINOGENESIS | - |
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dc.description.tc | 8 | - |
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