Publications
Detailed Information
Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women
Cited 155 time in
Web of Science
Cited 168 time in Scopus
- Authors
- Issue Date
- 2009-08
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Citation
- ENVIRONMENTAL RESEARCH; Vol.109 6; 797-801
- Keywords
- Bisphenol A ; Cross-sectional studies ; Oxidative stress ; Inflammation ; Postmenopausal woman
- Abstract
- Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MIDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 mu g/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects. (C) 2009 Elsevier Inc. All rights reserved.
- ISSN
- 0013-9351
- Language
- English
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.