Publications
Detailed Information
Comparison of Four Pancreatic Islet Implantation Sites
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyoung-Il | - |
dc.contributor.author | Yu, Jae Eun | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.contributor.author | Kim, Sang-Joon | - |
dc.date.accessioned | 2012-06-11T02:10:05Z | - |
dc.date.available | 2012-06-11T02:10:05Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 2; 203-210 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76942 | - |
dc.description.abstract | Although the liver is the most common site for pancreatic islet transplantation, it is not optimal. We compared kidney, liver, muscle, and omentum as transplantation sites with regard to operative feasibility, and the efficiency of implantation and glycemic control. Islets from C57BL/6 mice were transplanted into diabetic syngeneic recipients. The mean operative time and mortality were measured to assess feasibility. To assess implantation efficiency, the marginal mass required to cure diabetes and the mean time taken to achieve normoglycemia were measured. A glucose tolerance test was performed to assess glycemic control efficiency. The data are listed in the order of the kidney, liver, muscle, and omentum, respectively. The mean mortality rate was 6.7, 20.0, 7.1, and 12.5%; the mean operative time was 10.2, 27.4, 11.2, and 19.8 min; the marginal islet mass was 100, 600, 600, and 200 islet equivalence units and the mean time to reach euglycemia was 3.0, 15.1, 26.6, and 13.9 days. The glucose kinetics of omental pouch islets was the most similar to controls. Thus, a strategic approach is required for deciding on the best transplantation recipient sites after considering donor sources and islet volume. Alternatives can be chosen based on safety or efficacy. | ko_KR |
dc.description.sponsorship | This work was supported by a grant from the Korea
Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (Project No. A040004). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | Islets of Langerhans | ko_KR |
dc.subject | Kidney | ko_KR |
dc.subject | Muscles | ko_KR |
dc.subject | Transplantation | ko_KR |
dc.subject | Omentum | ko_KR |
dc.subject | Liver | ko_KR |
dc.title | Comparison of Four Pancreatic Islet Implantation Sites | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김형일 | - |
dc.contributor.AlternativeAuthor | 유재은 | - |
dc.contributor.AlternativeAuthor | 박청규 | - |
dc.contributor.AlternativeAuthor | 김상준 | - |
dc.identifier.doi | 10.3346/jkms.2010.25.2.203 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.description.citedreference | Korsgren O, 2008, DIABETOLOGIA, V51, P227, DOI 10.1007/s00125-007-0868-9 | - |
dc.description.citedreference | Caiazzo R, 2007, TRANSPL P, V39, P2620, DOI 10.1016/j.transproceed.2007.08.015 | - |
dc.description.citedreference | Yonekawa Y, 2006, TRANSPLANTATION, V82, P712, DOI 10.1097/01.tp.0000234906.29193.a6 | - |
dc.description.citedreference | Dombrowski F, 2006, CANCER RES, V66, P1833, DOI 10.1158/0008-5472.CAN-05-2787 | - |
dc.description.citedreference | Juang JH, 2005, TRANSPLANT P, V37, P3479, DOI 10.1016/j.transproceed.2005.09.023 | - |
dc.description.citedreference | Ryan EA, 2005, DIABETES, V54, P2060 | - |
dc.description.citedreference | Hughes SJ, 2003, TRANSPLANTATION, V75, P1954, DOI 10.1097/01.TP.0000066805.39716.23 | - |
dc.description.citedreference | Kin T, 2003, AM J TRANSPLANT, V3, P281 | - |
dc.description.citedreference | Tchervenivanov N, 2002, CELL TRANSPLANT, V11, P529 | - |
dc.description.citedreference | Bennet W, 2001, TRANSPLANTATION, V72, P312 | - |
dc.description.citedreference | Shapiro AMJ, 2000, NEW ENGL J MED, V343, P230 | - |
dc.description.citedreference | Bennet W, 1999, DIABETES, V48, P1907 | - |
dc.description.citedreference | Jindal RM, 1998, TRANSPLANT P, V30, P398 | - |
dc.description.citedreference | ALABDULLAH IH, 1995, CELL TRANSPLANT, V4, P297 | - |
dc.description.citedreference | AO ZL, 1993, TRANSPLANTATION, V56, P524 | - |
dc.description.citedreference | HILLER WFA, 1991, DIABETES, V40, P134 | - |
dc.description.citedreference | KAUFMAN DB, 1990, TRANSPLANTATION, V50, P385 | - |
dc.description.citedreference | KAMEI T, 1989, DIABETOLOGIA, V32, P779 | - |
dc.description.citedreference | GRAY DWR, 1988, J SURG RES, V45, P432 | - |
dc.description.citedreference | ALEJANDRO R, 1986, J CLIN INVEST, V78, P1339 | - |
dc.description.citedreference | MELLGREN A, 1986, DIABETOLOGIA, V29, P670 | - |
dc.description.citedreference | YASUNAMI Y, 1983, TRANSPLANTATION, V36, P181 | - |
dc.description.citedreference | AXEN KV, 1981, TRANSPLANTATION, V31, P439 | - |
dc.description.citedreference | KEMP CB, 1973, DIABETOLOGIA, V9, P486 | - |
dc.description.tc | 5 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.