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The Role of Indoleamine 2,3-Dioxygenase in Retinal Pigment Epithelial Cell-mediated Immune Modulation
DC Field | Value | Language |
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dc.contributor.author | Park, Choul Yong | - |
dc.contributor.author | Yang, Seung-Ha | - |
dc.contributor.author | Chuck, Roy S. | - |
dc.contributor.author | Gehlbach, Peter L. | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.date.accessioned | 2012-06-11T02:14:52Z | - |
dc.date.available | 2012-06-11T02:14:52Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | OCULAR IMMUNOLOGY AND INFLAMMATION; Vol.18 1; 24-31 | ko_KR |
dc.identifier.issn | 0927-3948 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76944 | - |
dc.description.abstract | Purpose: To evaluate the role of indoleamine dioxygenase (IDO) in human retinal pigment epithelial cell (RPE)-mediated immune modulation. Methods: The immunosuppression of cultured human RPEs (ARPE-19 cells) was assayed using the mixed lymphocyte reaction (MLR) harvested from CBA/J and BALB/c mice. The expression of critical immune modulatory molecules, such as class II major histocompatibility complex (MHC) molecules, co-stimulatory molecules (B7-1 and B7-2), and indoleamine dioxygenase (IDO), was examined by reverse transcriptase polymerase chain reaction, flow cytometry, and immunofluorescence staining with and without IFN-gamma stimulation. Results: RPEs expressed IDO and class II MHC molecules under IFN-gamma stimulation. However, B7-1 and B7-2 were not expressed. RPE significantly suppressed MLR in the absence of IFN-gamma prestimulation. This phenomenon was enhanced by IFN-gamma stimulation. The addition of 1-methyl tryptophan l into the culture medium successfully reversed RPE immunosuppression. Conclusions: The expression of IDO may in part explain RPE-mediated immune suppression effects. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Informa Healthcare | ko_KR |
dc.subject | co-stimulatory molecule | ko_KR |
dc.subject | 3-dioxygenase | ko_KR |
dc.subject | major histocompatibility complex | ko_KR |
dc.subject | Indoleamine 2 | ko_KR |
dc.subject | Immune modulation | ko_KR |
dc.subject | retinal pigment epithelium | ko_KR |
dc.title | The Role of Indoleamine 2,3-Dioxygenase in Retinal Pigment Epithelial Cell-mediated Immune Modulation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박철용 | - |
dc.contributor.AlternativeAuthor | 양승하 | - |
dc.contributor.AlternativeAuthor | 박청규 | - |
dc.identifier.doi | 10.3109/09273940903326203 | - |
dc.citation.journaltitle | OCULAR IMMUNOLOGY AND INFLAMMATION | - |
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