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Association of Increased Pulmonary Interleukin-6 with the Priming Effect of Intra-Amniotic Lipopolysaccharide on Hyperoxic Lung Injury in a Rat Model of Bronchopulmonary Dysplasia
DC Field | Value | Language |
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dc.contributor.author | Kim, Do-Hyun | - |
dc.contributor.author | Choi, Chang Won | - |
dc.contributor.author | Kim, Ee-Kyung | - |
dc.contributor.author | Kim, Han-Suk | - |
dc.contributor.author | Choi, Jung-Hwan | - |
dc.contributor.author | Yang, Eun Gyeong | - |
dc.contributor.author | Lee, Myong Jin | - |
dc.contributor.author | Kim, Beyong Il | - |
dc.date.accessioned | 2012-06-12T04:27:27Z | - |
dc.date.available | 2012-06-12T04:27:27Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | NEONATOLOGY; Vol.98 1; 23-32 | ko_KR |
dc.identifier.issn | 1661-7800 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76994 | - |
dc.description.abstract | Background: The authors previously demonstrated the priming effect of intra-amniotic lipopolysaccharide (LPS) on hyperoxic lung injury in a rat model of bronchopulmonary dysplasia (BPD). Objectives: To investigate the mechanism underlying this priming effect by determining biochemical profiles in a rat model of BPD. Methods: The rat model involved intra-amniotic LPS administration and postnatal hyperoxia (85%). The mRNA expressions of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR-2), basic fibroblast growth factor (bFGF), and transforming growth factor beta(1) (TGF-beta(1)), as well as the protein levels of IL-6, VEGF, and protein carbonyl in lung tissue were compared between the LPS plus hyperoxia, the LPS only, the hyperoxia only, and the control groups. Results: Morphometric analysis of lung tissues demonstrated that alveolarization was significantly inhibited only in the LPS plus hyperoxia group. IL-6 protein levels and its mRNA expression in the lungs were significantly increased only in the LPS plus hyperoxia group. Neither LPS nor hyperoxia increased IL-6 in the lungs independently. bFGF mRNA expression was significantly decreased in the LPS-treated groups. VEGF protein levels were significantly reduced by hyperoxia, whereas protein carbonyl levels were increased by intra-amniotic LPS or hyperoxia. No additional significant change to VEGF or protein carbonyl levels was produced by intra-amniotic LPS or hyperoxia. There were no significant differences in the mRNA expressions of VEGF, VEGFR-2, and TGF-beta 1. Conclusions: The priming effect of intra-amniotic LPS on hyperoxic lung injury may be associated with IL-6 elevation in the lungs. Copyright (C) 2009 S. Karger AG, Basel | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KARGER | ko_KR |
dc.subject | Alveolarization | ko_KR |
dc.subject | Bronchopulmonary dysplasia | ko_KR |
dc.subject | Inflammation | ko_KR |
dc.subject | Interleukin-6 | ko_KR |
dc.title | Association of Increased Pulmonary Interleukin-6 with the Priming Effect of Intra-Amniotic Lipopolysaccharide on Hyperoxic Lung Injury in a Rat Model of Bronchopulmonary Dysplasia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김도현 | - |
dc.contributor.AlternativeAuthor | 최창원 | - |
dc.contributor.AlternativeAuthor | 김이경 | - |
dc.contributor.AlternativeAuthor | 김한석 | - |
dc.contributor.AlternativeAuthor | 김병일 | - |
dc.contributor.AlternativeAuthor | 최중환 | - |
dc.contributor.AlternativeAuthor | 이명진 | - |
dc.contributor.AlternativeAuthor | 양은경 | - |
dc.identifier.doi | 10.1159/000263056 | - |
dc.citation.journaltitle | NEONATOLOGY | - |
dc.description.citedreference | CHOI CW, 2009, PEDIATR RES, V65, pR323 | - |
dc.description.citedreference | CHEAH FC, 2008, PEDIATR RES, V63, pR274 | - |
dc.description.citedreference | Kunzmann S, 2007, AM J PHYSIOL-LUNG C, V292, pL223, DOI 10.1152/ajplung.00159.2006 | - |
dc.description.citedreference | Thebaud B, 2007, NEONATOLOGY, V91, P291, DOI 10.1159/000101344 | - |
dc.description.citedreference | Speer CP, 2006, SEMIN FETAL NEONAT M, V11, P354, DOI 10.1016/j.siny.2006.03.004 | - |
dc.description.citedreference | Choi CW, 2006, ACTA PAEDIATR, V95, P38, DOI 10.1080/08035250500404085 | - |
dc.description.citedreference | UEDA K, 2006, PEDIATR RES, V59, pR396 | - |
dc.description.citedreference | Bourbon J, 2005, PEDIATR RES, V57, p38R | - |
dc.description.citedreference | Kallapur SG, 2004, AM J PHYSIOL-LUNG C, V287, pL1178, DOI 10.1152/ajplung.00049.2004 | - |
dc.description.citedreference | JANKOV RP, 2004, PAEDIATR RESPIR REV, V5, pS265 | - |
dc.description.citedreference | Hosford GE, 2003, AM J PHYSIOL-LUNG C, V285, pL161, DOI 10.1152/ajplung.00285.2002 | - |
dc.description.citedreference | Mitchell GB, 2003, INFECT IMMUN, V71, P1643, DOI 10.1128/IAI.71.41643-1649.2003 | - |
dc.description.citedreference | Ambalavanan N, 2003, PEDIATR RES, V53, P240, DOI 10.1203/01.PDR.0000047656.17766.39 | - |
dc.description.citedreference | SPEER CP, 2003, SEMIN NEONATOL, V8, P29 | - |
dc.description.citedreference | JOBE AH, 2003, SEMIN NEONATOL, V8, P9 | - |
dc.description.citedreference | SAUGSTAD OD, 2003, SEMIN NEONATOL, V8, P39 | - |
dc.description.citedreference | Ikegami M, 2002, PEDIATR RES, V52, P356, DOI 10.1203/01.PDR.0000030715.99576.E7 | - |
dc.description.citedreference | Kramer BW, 2002, AM J PHYSIOL-LUNG C, V283, pL452, DOI 10.1152/ajplung.00407.2001 | - |
dc.description.citedreference | Van Marter LJ, 2002, J PEDIATR, V140, P171, DOI 10.1067/mpd.2002.121381 | - |
dc.description.citedreference | Lecart C, 2000, BIOL NEONATE, V77, P217 | - |
dc.description.citedreference | WILLET KE, 2000, PEDIATR RES, V48, pR782 | - |
dc.description.citedreference | Yoon BH, 1999, AM J OBSTET GYNECOL, V181, P773 | - |
dc.description.citedreference | DeLeo FR, 1998, J CLIN INVEST, V101, P455 | - |
dc.description.citedreference | Kotecha S, 1996, J PEDIATR, V128, P464 | - |
dc.description.citedreference | KOTECHA S, 1996, PEDIATR RES, V40, pR250 | - |
dc.description.citedreference | POWERS MR, 1994, J CELL BIOCHEM, V56, P536 | - |
dc.description.citedreference | GLADSTONE IM, 1994, PEDIATRICS, V93, P764 | - |
dc.description.citedreference | BRETTELL LM, 1994, AM J RESP CELL MOL, V10, P306 | - |
dc.description.citedreference | FRANK L, 1991, FREE RADICAL BIO MED, V11, P463 | - |
dc.description.citedreference | WEIBEL ER, 1963, MORPHOMETRY HUMAN LU | - |
dc.description.tc | 1 | - |
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