S-Space College of Medicine/School of Medicine (의과대학/대학원) Neurosurgery (신경외과학전공) Journal Papers (저널논문_신경외과학전공)
DEVELOPMENT OF DOSE-VOLUME RELATION MODEL FOR GAMMA KNIFE SURGERY OF NON-SKULL BASE INTRACRANIAL MENINGIOMAS
Cited 9 time in Web of Science Cited 11 time in Scopus
- Issue Date
- ELSEVIER SCIENCE INC
- INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS; Vol.74 4; 1027-1032
- Radiosurgery ; Meningioma ; Radiation dose ; Radiation injury ; Complications
- Preliminary results presented at the 13th International Meeting of
the Leksell Gamma Knife Society, Seoul, Korea, May 2006.
- Purpose: To provide a dose-volume relationship for gamma knife surgery (GKS) of non-skull base intracranial meningiomas. Methods and Materials: The radiologic outcomes of GKS of 82 imaging-defined benign meningiomas located at non-skull base areas were analyzed. A total of 80 patients were included and all underwent treatment with GKS as the first and the only treatment modality. The mean patient age was 55.0 years (range, 26-78) and the mean tumor volume was 5.6 cm(3) (range, 0.5-16.8). On average, 14.6 Gy (range, 10-20) was applied to the 50% isodose surface. The binary logistic regression method was applied to find prognostic factors of signal change (SC) on T(2)-weighted magnetic resonance imaging after GKS. Results: The actuarial tumor control rate was 91.6% at 5 years. A total of 29 lesions (35.4%) showed newly developed or aggravated SCs. The volume irradiated >= 14 Gy was the only statistically significant (p < .01) prognostic factor of SC. A dose-volume relation model obtained from the cases without SC estimated a 12.2% SC probability. Conclusion: This model can be used in GKS to treat small- to medium-size (<9.2 cm(3)) non-skull base meningiomas.
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