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Preventive effects of COX-2 inhibitor, celecoxib on renal tubular injury induced by shock wave lithotriptor
DC Field | Value | Language |
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dc.contributor.author | Park, Hyoung Keun | - |
dc.contributor.author | Lee, Hae Won | - |
dc.contributor.author | Lee, Kwang Soo | - |
dc.contributor.author | Choi, Jong Sun | - |
dc.contributor.author | Kim, Hyeon Hoe | - |
dc.contributor.author | Jeong, Byong Chang | - |
dc.date.accessioned | 2012-06-14T06:43:23Z | - |
dc.date.available | 2012-06-14T06:43:23Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.citation | UROLOGICAL RESEARCH; Vol.38 4; 223-228 | ko_KR |
dc.identifier.issn | 0300-5623 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77076 | - |
dc.description.abstract | Our study was designed to investigate the protective effect of the COX-2 inhibitor, celecoxib, on renal tubules against shock wave lithotripsy (SWL). Sprague-Dawley rats were randomly divided into three groups: sham, control, and COX-2 groups. The control group was administrated normal saline. The COX-2 group was administered celecoxib (10 mg/kg). After administration for 1 week, the control and COX-2 groups received 1,000 shock waves. Before and after SWL, 24-h urine was collected. CCr was measured to assess renal function. To determine the renal tubular injury, N-acetyl glucosaminidase (NAG) and beta-2 microglobulin levels in urine were quantified. The COX-2 gene expression was compared between the three groups. Prior to SWL, all groups had similar levels of NAG and beta-2 microglobulin. After SWL, all groups showed similar CCr. Compared with the sham group, control and COX-2 groups produced increase of NAG and beta-2 microglobulin excretion. However, NAG and beta-2 microglobulin excretions were significantly lower in the COX-2 group than control group. The COX-2 gene expression did not increase in the sham group. However, the COX-2 gene expression was significantly increased in the control group, which was prevented by celecoxib in COX-2 group. Biochemical findings supported a renal protective effect of celecoxib on SWL. This study suggests that celecoxib would be useful prior and after SWL because of renal protective effects. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.subject | Kidney | ko_KR |
dc.subject | COX-2 inhibitors | ko_KR |
dc.subject | Extracorporeal shockwave lithotripsy | ko_KR |
dc.title | Preventive effects of COX-2 inhibitor, celecoxib on renal tubular injury induced by shock wave lithotriptor | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박형근 | - |
dc.contributor.AlternativeAuthor | 이해원 | - |
dc.contributor.AlternativeAuthor | 이광수 | - |
dc.contributor.AlternativeAuthor | 최종선 | - |
dc.contributor.AlternativeAuthor | 정병창 | - |
dc.contributor.AlternativeAuthor | 김현회 | - |
dc.identifier.doi | 10.1007/s00240-009-0243-z | - |
dc.citation.journaltitle | UROLOGICAL RESEARCH | - |
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dc.description.tc | 2 | - |
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