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Longitudinal Change in Outcome of Frontal Lobe Epilepsy Surgery

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Authors
Kim, Chi Heon; Chung, Chun Kee; Lee, Sang Kun
Issue Date
2010-11
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
NEUROSURGERY; Vol.67 5; 1222-1229
Keywords
EpilepsyFrontal lobeSurgeryMagnetic resonance imagingLongitudinal study
Abstract
BACKGROUND: Although the outcome of epilepsy surgery changes with time, few studies have considered longitudinal changes after frontal lobe epilepsy (FLE) surgery. OBJECTIVE: To assess the longitudinal changes after FLE surgery. METHODS: Resection of the seizure onset zone was performed in 76 patients with FLE. Invasive monitoring was performed in 56 of these 76. Awake craniotomy was performed in 43 of the 76 patients. More than 50% of patients were followed up for at least 7 years. The mean follow-up was 81 months. RESULTS: For all patients, the seizure-free rate was 79% at 6 months, 64% at 1 year, 55% at 2 years, and 55% at 7 years. For patients with cortical dysplasia, the seizure-free rate was 72% at 6 months, 53% at 1 year, 51% at 2 years, and 46% at 7 years. For patients with tumor, the seizure-free rate was 89% at 6 months, 83% at 1 year, 83% at 2 years, and 74% at 7 years. Patients with tumor showed better outcome than those with cortical dysplasia (P = .04). Although the overall seizure-free rate became stable after 2 years, individual status changed for up to 5 years. Seizures recurred in 11 patients within 1 year (early recurrence) and in 12 patients by 1 to 5 years (late recurrence). Antiepileptic drug (AED) medication was adjusted in all patients with recurrence. Patients with late recurrence had a more favorable response (Engel class I or II) than early recurrence (P < .01). CONCLUSION: The overall seizure outcome changes mostly during the first year. However, individual seizure status changes for up to 5 years. The outcome of late recurrence is favorable to AED adjustment.
ISSN
0148-396X
Language
English
URI
https://hdl.handle.net/10371/77114
DOI
https://doi.org/10.1227/NEU.0b013e3181f2380b
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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