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Assessment of Language Dominance by Event-Related Oscillatory Changes in an Auditory Language Task: Magnetoencephalography Study

Cited 5 time in Web of Science Cited 7 time in Scopus
Authors
Lee, Seo-Young; Kim, June Sic; Chung, Chun Kee; Lee, Sang Kun; Kim, Won Sup
Issue Date
2010-08
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
JOURNAL OF CLINICAL NEUROPHYSIOLOGY; Vol.27 4; 263-269
Keywords
Event-related desynchronization (ERD)Magnetoencephalography (MEG)LanguageEvent-related synchronization (ERS)Gamma
Abstract
The authors investigated the oscillatory changes induced by auditory language task to assess hemispheric dominance of language. Magnetoencephalography studies were conducted during word listening in 6 normal right-handed volunteers and 13 epilepsy patients who underwent Wada test. We carried out a time-frequency analysis of event-related desynchronization (ERD)/event-related synchronization (ERS) and intertrial coherence. We localized ERD/ERS on each subject`s magnetic resonance images using beamformer. We compared ERD/ERS values between the left and right side of regions of interest in inferior frontal and superior temporal areas. We assessed the target frequency range that correlated best with the Wada test results. In all normal subjects, gamma ERD was lateralized to the left side in both the inferior frontal and superior temporal areas. In epilepsy patients, the concordance rate of gamma ERD and the Wada test results was 76.9% for the inferior frontal area and 69.2% for the superior temporal area. Gamma ERD can be considered as an indicator of language function, although it was not sufficient to replace the Wada test in the evaluation of epilepsy patients. The gamma ERD value of the inferior frontal area was more reliable for the assessment of language dominance compared with that obtained in the superior temporal area.
ISSN
0736-0258
Language
English
URI
https://hdl.handle.net/10371/77117
DOI
https://doi.org/10.1097/WNP.0b013e3181eaaf3c
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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