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Evaluation of 28 Human Embryonic Stem Cell Lines for Use as Unrelated Donors in Stem Cell Therapy: Implications of HLA and ABO Genotypes

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dc.contributor.authorLee, Jeoung Eun-
dc.contributor.authorKang, Myung Seo-
dc.contributor.authorShim, Sung Han-
dc.contributor.authorPark, Myoung Hee-
dc.contributor.authorChung, Hyung Min-
dc.contributor.authorLee, Dong Ryul-
dc.contributor.authorYoon, Tae Ki-
dc.date.accessioned2012-06-25T02:07:10Z-
dc.date.available2012-06-25T02:07:10Z-
dc.date.issued2010-
dc.identifier.citationCELL TRANSPLANTATION; Vol.19 11; 1383-1395ko_KR
dc.identifier.issn0963-6897-
dc.identifier.urihttps://hdl.handle.net/10371/77364-
dc.description.abstractFor human embryonic stem cells (hESCs) to be used clinically, it is imperative that immune responses evoked by hESCs and their derivates after transplantation should be prevented. Human leukocyte antigens (HLA) and ABO blood group antigens are important histocompatibility factors in graft rejection. HLA matching between recipient and unrelated donors, in particular, is important in improving outcomes in hematopoietic cell transplantation (HCT). We have established and successfully maintained 29 hESC lines and analyzed the HLA and ABO genotypes of these lines. HLA-A, -B, -C and -DR (DRB1) genotyping was performed by polymerase chain reaction (PCR) sequence-based typing and ABO genotyping was carried out by PCR restriction fragment length polymorphism methods. To determine what proportion of the Korean population would be covered by these cell lines in organ transplantation, 27 cell lines with HLA-A, -B, and -DR data were evaluated for HCT (cord blood) donors and 28 cell lines with HLA-DR and ABO data were evaluated for solid organ (kidney) transplantation donors, and then compared the data with those from 6,740 donated cord bloods. When <= 2 HLA mismatches are allowed for HCT, as currently accepted for cord blood transplantation, it was estimated that about 16% and 25% of the possible recipients can find one or more donor cell lines with mismatches at A, B, DRB1 allele level and at A, B antigen/DRB1 allele level, respectively. When HLA-DR antigen level matching and ABO compatibility was considered for solid organ (kidney) transplantation, it was estimated that about 29% and 96% of the possible recipients can find one or more ABO-compatible donor cell lines with 0 and 1 DR mismatches, respectively. We provided the first report on the HLA and ABO genotypes of hESC lines, and estimated the degree of HLA and ABO matching in organ transplantation for the Korean population.ko_KR
dc.language.isoenko_KR
dc.publisherCOGNIZANT COMMUNICATION CORPko_KR
dc.subjectHuman embryonic stem cells (hESCs)ko_KR
dc.subjectCell therapyko_KR
dc.subjectDonated cord bloodko_KR
dc.subjectHLA genotypeko_KR
dc.subjectABO genotypeko_KR
dc.titleEvaluation of 28 Human Embryonic Stem Cell Lines for Use as Unrelated Donors in Stem Cell Therapy: Implications of HLA and ABO Genotypesko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이정은-
dc.contributor.AlternativeAuthor심성한-
dc.contributor.AlternativeAuthor윤태기-
dc.contributor.AlternativeAuthor이동률-
dc.contributor.AlternativeAuthor정형민-
dc.contributor.AlternativeAuthor강명서-
dc.contributor.AlternativeAuthor박명희-
dc.identifier.doi10.3727/096368910X513991-
dc.citation.journaltitleCELL TRANSPLANTATION-
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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