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Detection of Differential Proteomes of Human beta-Cells During Islet-Like Differentiation Using iTRAQ Labeling

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dc.contributor.authorJin, Jonghwa-
dc.contributor.authorPark, Jungeun-
dc.contributor.authorKim, Kyunggon-
dc.contributor.authorKang, Yup-
dc.contributor.authorKim, Jae Hyeon-
dc.contributor.authorJun, Heesook-
dc.contributor.authorKim, Youngsoo-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorPark, Sang Gyu-
dc.date.accessioned2012-06-26T00:23:20Z-
dc.date.available2012-06-26T00:23:20Z-
dc.date.issued2009-03-
dc.identifier.citationJOURNAL OF PROTEOME RESEARCH; Vol.8 3; 1393-1403ko_KR
dc.identifier.issn1535-3893-
dc.identifier.urihttps://hdl.handle.net/10371/77409-
dc.description.abstractA human beta-cell line, RNAKT-15, was recently established from human pancreatic islets, whereby its differentiation into islet-like beta-cells (islet-like RNAKT-15) increased its expression of insulin 2-fold compared with RNAKT-15 cells. To characterize the differentiation of RNAKT-15 cells into islet-like RNAKT-15, microarray and quantitative proteomics were performed. Our analysis of differential proteomic and mRNA expression has resulted in a greater understanding of the molecular functions that are involved in beta-cell differentiation and insulin synthesis and release.ko_KR
dc.description.sponsorshipThis work was supported by the
21C Frontier Functional Proteomics Project of the Korean
Ministry of Science and Technology (grant no. FPR
08-A2-110) and by a grant of the Korea Health 21 R&D
Project, Ministry for Health, Welfare and Family Affairs, ROK
(A030003).		ko_KR
dc.language.isoenko_KR
dc.publisherAMER CHEMICAL SOCko_KR
dc.subjecthuman beta-cell lineko_KR
dc.subjectRNAKT-15 cellko_KR
dc.subjectiTRAQko_KR
dc.subjectislet transplantationko_KR
dc.subjectbeta-cell differentiationko_KR
dc.titleDetection of Differential Proteomes of Human beta-Cells During Islet-Like Differentiation Using iTRAQ Labelingko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor진종화-
dc.contributor.AlternativeAuthor박정은-
dc.contributor.AlternativeAuthor김경곤-
dc.contributor.AlternativeAuthor강엽-
dc.contributor.AlternativeAuthor박상규-
dc.contributor.AlternativeAuthor김재현-
dc.contributor.AlternativeAuthor박경수-
dc.contributor.AlternativeAuthor전희숙-
dc.contributor.AlternativeAuthor김영수-
dc.identifier.doi10.1021/pr800765t-
dc.citation.journaltitleJOURNAL OF PROTEOME RESEARCH-
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