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Transcriptome analysis of hepatitis B virus-associated small hepatocellular carcinoma by serial analysis of gene expression
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin-Wook | - |
dc.contributor.author | Lee, Sang Hyub | - |
dc.contributor.author | Park, Young Soo | - |
dc.contributor.author | Jeong, Sook-Hyang | - |
dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.contributor.author | Kim, Nayoung | - |
dc.date.accessioned | 2012-06-26T00:44:42Z | - |
dc.date.available | 2012-06-26T00:44:42Z | - |
dc.date.issued | 2009-07 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF ONCOLOGY; Vol.35 1; 129-137 | ko_KR |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77413 | - |
dc.description.abstract | Serial analysis of gene expression (SAGE) is a sequence-based tool that enables quantitative study of comprehensive gene expression profiles. In this Study, we generated a SAGE library of hepatitis B virus (HBV)associated small hepatocellular carcinoma (HCC) and compared it with libraries of normal liver and other organs in order to identify genes which are specifically expressed in HBV-associated small HCC. A total of 18,107 SAGE tags were obtained from the HCC SAGE library. Among the 7,405 unique tags, 240 were significantly overexpressed in HCC compared to normal liver. Seventeen genes were unequivocally matched to SAGE tags which were up-regulated 15-fold or higher in HCC compared to normal liver: four genes (fatty acid desaturase 2, alpha-L-2-fucosidase, testis-specific protein Y-encoded-like 2 and Gon-4-like) were significantly overexpressed in the HCC SAGE library compared to any other SAGE libraries of human normal tissues. The significance of these genes with respect to carcinogenesis and early diagnosis of HCC needs to be elucidated in further studies. | ko_KR |
dc.description.sponsorship | This study was supported by grant 03-2004-007 from the
SNUBH Research Fund to Dr J.W. Kim. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPANDIDOS PUBL LTD | ko_KR |
dc.subject | hepatitis B virus | ko_KR |
dc.subject | hepatocellular carcinoma | ko_KR |
dc.subject | serial analysis of gene expression | ko_KR |
dc.subject | transcriptome | ko_KR |
dc.title | Transcriptome analysis of hepatitis B virus-associated small hepatocellular carcinoma by serial analysis of gene expression | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김진욱 | - |
dc.contributor.AlternativeAuthor | 이상협 | - |
dc.contributor.AlternativeAuthor | 박영수 | - |
dc.contributor.AlternativeAuthor | 정숙향 | - |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 이동호 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.identifier.doi | 10.3892/ijo_00000321 | - |
dc.citation.journaltitle | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
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dc.description.tc | 1 | - |
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