Publications

Detailed Information

FN13762 Murine Breast Cancer: Region-by-Region Correlation of First-Pass Perfusion CT Indexes with Histologic Vascular Parameters

DC Field Value Language
dc.contributor.authorPark, Chang Min-
dc.contributor.authorGoo, Jin Mo-
dc.contributor.authorLee, Hyun Ju-
dc.contributor.authorKim, Min A-
dc.contributor.authorKim, Kwang Gi-
dc.contributor.authorIm, Jung-Gi-
dc.contributor.authorLee, Chang Hyun-
dc.contributor.authorKim, Hyo-Cheol-
dc.date.accessioned2012-06-26T05:35:59Z-
dc.date.available2012-06-26T05:35:59Z-
dc.date.issued2009-06-
dc.identifier.citationRADIOLOGY; Vol.251 3; 721-730ko_KR
dc.identifier.issn0033-8419-
dc.identifier.urihttps://hdl.handle.net/10371/77434-
dc.description.abstractPurpose: To investigate the correlation between first-pass perfusion computed tomographic (CT) indexes and histologic vascular parameters in FN13762 breast cancer in rats by using region-by-region correlation methods. Materials and Methods: The Animal Care and Use Committee approved this study. FN13762 murine breast cancer cells were implanted in 14 female Fischer 344 rats, and first-pass perfusion CT was performed. CT perfusion maps depicting blood flow, blood volume, mean transit time (MTT), and permeability-surface area (PSA) product were generated by using commercial perfusion software. The entire tumor area was divided into six separate regions on perfusion maps, and the regional perfusion indexes were quantified. Histologic vascular parameters, including microvessel density (MVD), luminal vessel number, luminal vessel area, and luminal vessel perimeter, were measured in the histologic region corresponding to the perfusion maps. Correlation analysis was performed between regional tumor perfusion indexes and histologic vascular parameters of the corresponding tumor region. Additionally, mean perfusion values of the entire tumor were correlated with histologic vascular parameters of the hot spot within the tumor. Among 14 rats, four were excluded from the analysis, and results were based on a final total of 10 rats. Results: In tumors, blood flow, blood volume, and PSA product were significantly higher and MTT was significantly shorter (P < .05 for all) than these values in normal neck muscles. At region-by-region correlation, regional blood flow (r = 0.476), blood volume (r = 0.348), and MTT (r = -0.506) were significantly correlated with MVD in the corresponding tumor region (P < .01 for all). After adjustment for biologic variability between rats, regional blood flow (r = 0.614), blood volume (r = 0.515), MTT (r = -0.524), and PSA product (r = 0.228) remained significantly correlated with MVD in the corresponding tumor region. Correlation analysis between CT perfusion indexes of the entire tumor and histologic vascular parameters of the hot spot did not show significant correlations (P = .05). Conclusion: Regional blood flow, blood volume, and MTT are significantly correlated with MVD in the corresponding tumor region. (C) RSNA, 2009ko_KR
dc.language.isoenko_KR
dc.publisherRADIOLOGICAL SOC NORTH AMERICAko_KR
dc.titleFN13762 Murine Breast Cancer: Region-by-Region Correlation of First-Pass Perfusion CT Indexes with Histologic Vascular Parametersko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박창민-
dc.contributor.AlternativeAuthor구진모-
dc.contributor.AlternativeAuthor이현주-
dc.contributor.AlternativeAuthor김민아-
dc.contributor.AlternativeAuthor김효철-
dc.contributor.AlternativeAuthor김광기-
dc.contributor.AlternativeAuthor이창현-
dc.contributor.AlternativeAuthor임정기-
dc.identifier.doi10.1148/radiol.2513081215-
dc.citation.journaltitleRADIOLOGY-
dc.description.citedreferenceGoh V, 2008, RADIOLOGY, V247, P726, DOI 10.1148/radiol.2473070414-
dc.description.citedreferenceTorigan DA, 2007, CA-CANCER J CLIN, V57, P206-
dc.description.citedreferenceSahani DV, 2007, RADIOLOGY, V243, P736, DOI 10.1148/radiol.2433052020-
dc.description.citedreferenceMotzer RJ, 2007, NEW ENGL J MED, V356, P115-
dc.description.citedreferenceKim CK, 2005, RADIOLOGY, V237, P529, DOI 10.1148/radiol.2372041634-
dc.description.citedreferenceKan ZX, 2005, RADIOLOGY, V237, P151, DOI 10.1148/radiol.2363041293-
dc.description.citedreferenceLi ZP, 2005, WORLD J GASTROENTERO, V11, P1287-
dc.description.citedreferenceSahani DV, 2005, RADIOLOGY, V234, P785, DOI 10.1148/radiol.2343040286-
dc.description.citedreferenceYi CA, 2004, RADIOLOGY, V233, P191, DOI 10.1148/radiol.2331031535-
dc.description.citedreferenceHurwitz H, 2004, NEW ENGL J MED, V350, P2335-
dc.description.citedreferenceJohnson DH, 2004, J CLIN ONCOL, V22, P2184, DOI 10.1200/JCO.2004.11.022-
dc.description.citedreferencePhongkitkarun S, 2004, ACAD RADIOL, V11, P573, DOI 10.1016/S1076-6332(03)00728-1-
dc.description.citedreferenceAlvarez E, 2003, CLIN CANCER RES, V9, P5705-
dc.description.citedreferenceMiles KA, 2003, BRIT J RADIOL, V76, P220, DOI 10.1259/bjr/13564625-
dc.description.citedreferenceVermeulen PB, 2002, EUR J CANCER, V38, P1564-
dc.description.citedreferenceRoberts HC, 2002, AM J NEURORADIOL, V23, P828-
dc.description.citedreferenceTateishi U, 2002, J COMPUT ASSIST TOMO, V26, P185-
dc.description.citedreferencePurdie TG, 2001, PHYS MED BIOL, V46, P3161, DOI 10.1088/0031-9155/46/12/307-
dc.description.citedreferenceJinzaki M, 2000, J COMPUT ASSIST TOMO, V24, P835-
dc.description.citedreferenceSchor AM, 1998, HISTOCHEM J, V30, P849-
dc.description.citedreferenceOmar WS, 1997, ANTICANCER RES, V17, P1639-
dc.description.citedreferenceFox SB, 1997, HISTOPATHOLOGY, V30, P294-
dc.description.citedreferenceWEIDNER N, 1995, AM J PATHOL, V147, P9-
dc.description.citedreferenceBLAND JM, 1995, BRIT MED J, V310, P446-
dc.description.citedreferenceWEIDNER N, 1991, NEW ENGL J MED, V324, P1-
dc.description.citedreferenceHINDMARSH T, 1975, ACTA RADIOL, V346, P45-
dc.description.citedreferenceSEGALOFF A, 1966, REC PROGR HORMONE RE, V22, P351-
dc.description.citedreference*US FDA, FDA APPR DRUG PROD-
dc.description.tc3-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share