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Neoadjuvant Chemotherapy Followed by Limited Surgery in a Mouse Model of Head and Neck Cancer

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Authors
Lee, Jae Jin; Hah, Jeong-Hun; Im, Seock-Ah; Kim, Si-Young; Kim, Kwang Hyun; Heo, Dae Soeg; Sung, Myung-Whun
Issue Date
2009-01
Publisher
INT INST ANTICANCER RESEARCH
Citation
ANTICANCER RESEARCH; Vol.29 1; 255-259
Keywords
Head and neck cancerradical surgeryneoadjuvant chemotherapylimited surgeryprognosis
Abstract
Background: This study evaluated the effect of limited surgery following neoadjuvant chemotherapy compared to radical surgery in SCC VII (squamous cell cancer) tumor-bearing syngeneic C3H/HeJ mice. Materials and Methods: Mice showing a tumor response to cisplatin and 5-fluorouracil therapy were divided into three groups: radical surgery, with a 5 nun margin from the original tumor, group (A); limited surgery of 5 mm margin from the residual tumor, group (B); and very limited surgery with no margin from the residual tumor, group (C). The number of mice was 13 (group A), 12 (group B) and 12 (group C). Results: No recurrence developed except in one mouse in group C. Three mice died in group A, one in group B and one in group C from perioperative complications. By intent-to-treat analysis, the survival was not significantly different among the three groups (p=0.64), or between group A and B (p=0.33). Conclusion: The outcome of limited surgery was comparable to radical surgery after neoadjuvant chemotherapy in the mouse model of head and neck cancer.
ISSN
0250-7005
Language
English
URI
http://hdl.handle.net/10371/77451
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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