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Glutathione Peroxidase 3 Mediates the Antioxidant Effect of Peroxisome Proliferator-Activated Receptor gamma in Human Skeletal Muscle Cells
DC Field | Value | Language |
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dc.contributor.author | Chung, Sung Soo | - |
dc.contributor.author | Kim, Min | - |
dc.contributor.author | Youn, Byoung-Soo | - |
dc.contributor.author | Lee, Nam Seok | - |
dc.contributor.author | Lee, In Kyu | - |
dc.contributor.author | Kim, Jae Bum | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Lee, Yun Sok | - |
dc.contributor.author | Park, Ji Woo | - |
dc.date.accessioned | 2012-06-26T06:15:47Z | - |
dc.date.available | 2012-06-26T06:15:47Z | - |
dc.date.issued | 2009-01-01 | - |
dc.identifier.citation | MOLECULAR AND CELLULAR BIOLOGY; Vol.29 1; 20-30 | ko_KR |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77452 | - |
dc.description.abstract | Oxidative stress plays an important role in the pathogenesis of insulin resistance and type 2 diabetes mellitus and in diabetic vascular complications. Thiazolidinediones (TZDs), a class of peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists, improve insulin sensitivity and are currently used for the treatment of type 2 diabetes mellitus. Here, we show that TZD prevents oxidative stress-induced insulin resistance in human skeletal muscle cells, as indicated by the increase in insulin-stimulated glucose uptake and insulin signaling. Importantly, TZD-mediated activation of PPAR gamma induces gene expression of glutathione peroxidase 3 (GPx3), which reduces extracellular H(2)O(2) levels causing insulin resistance in skeletal muscle cells. Inhibition of GPx3 expression prevents the antioxidant effects of TZDs on insulin action in oxidative stress-induced insulin-resistant cells, suggesting that GPx3 is required for the regulation of PPAR gamma-mediated antioxidant effects. Furthermore, reduced plasma GPx3 levels were found in patients with type 2 diabetes mellitus and in db/db/DIO mice. Collectively, these results suggest that the antioxidant effect of PPAR gamma is exclusively mediated by GPx3 and further imply that GPx3 may be a therapeutic target for insulin resistance and diabetes mellitus. | ko_KR |
dc.description.sponsorship | This study was supported by 21C Frontier Functional Proteomics
Project from the Korean Ministry of Education, Science and Technology and MarineBio21, Ministry of Maritime Affairs and Fisheries, South Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC MICROBIOLOGY | ko_KR |
dc.title | Glutathione Peroxidase 3 Mediates the Antioxidant Effect of Peroxisome Proliferator-Activated Receptor gamma in Human Skeletal Muscle Cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정성수 | - |
dc.contributor.AlternativeAuthor | 김민 | - |
dc.contributor.AlternativeAuthor | 윤병수 | - |
dc.contributor.AlternativeAuthor | 이남석 | - |
dc.contributor.AlternativeAuthor | 박지우 | - |
dc.contributor.AlternativeAuthor | 이인규 | - |
dc.contributor.AlternativeAuthor | 이윤속 | - |
dc.contributor.AlternativeAuthor | 김재범 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.identifier.doi | 10.1128/MCB.00544-08 | - |
dc.citation.journaltitle | MOLECULAR AND CELLULAR BIOLOGY | - |
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dc.description.tc | 19 | - |
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