S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Effect of fermented milk containing probiotics on symptoms in Korean adults with irritable bowel syndrome
- Issue Date
- WILEY-BLACKWELL PUBLISHING, INC
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY; Vol.24 ; A49-A49
- Background/aims Irritable bowel syndrome (IBS) is a chronic and
recurrent disease, and low-grade inflammation has been known as a key
factor in the pathogenesis of IBS. Using some strains of probiotics which
were reported to have remarkable immunomodulatory function, we
designed prospective double-blind randomized placebo-controlled clinical
study to investigate the effect of fermented milk containing probiotics in
Korean adults with IBS.
Methods IBS patients who met Rome III criteria were randomly assigned
to receive fermented milk containing functional probiotics or placebo.
Total 13 billion lyophilized bacteria (Lactobacillus brevis HY7401, Lactobacillus
sp. HY7801, and bifidobacterium longum HY8004) were
administered three times daily for 8 weeks. Primary outcome variables
were symptom scores consisting of abdominal pain, flatulence, defecation
discomfort and sum of symptom scores. A 100 mm visual analogue scale
was used to measure the severity. Secondary outcome variables consisted
of bowel habits including frequency and form. To assess the change of
small metabolites after treatment, metabolomic analysis was performed
using patients serum.
Results Thirty seven patients were randomized to the probiotics group
and 36 to the placebo. Intention-to-treat analysis showed significant
improvements after 8 weeks on defecation discomfort, -30.1 in probiotics
group vs. -16.3 in placebo (P = 0.031), and sum of scores, -85.6 vs. -51.9
respectively (P = 0.022). Defecation frequency was significantly changed
from baseline, -1.5 in probiotics group vs. 0.5 in placebo (P = 0.041).
Metabolomic analysis showed remarkable increase of lactate in patients
serum after probiotics treatment.
Conclusions Fermented milk containing functional probiotics was safe
and effective in IBS patients.
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