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Increased Urinary Lipocalin-2 Reflects Matrix Metalloproteinase-9 Activity in Chronic Hepatitis C with Hepatic Fibrosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin-Wook | - |
dc.contributor.author | Lee, Sang Hyub | - |
dc.contributor.author | Jeong, Sook-Hyang | - |
dc.contributor.author | Kim, Haeryoung | - |
dc.contributor.author | Cho, Jai Young | - |
dc.contributor.author | Han, Ho-Seong | - |
dc.contributor.author | Yoon, Yoo-Seok | - |
dc.contributor.author | Ahn, Keun Soo | - |
dc.date.accessioned | 2012-06-27T07:39:52Z | - |
dc.date.available | 2012-06-27T07:39:52Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE; Vol.222 4; 319-327 | ko_KR |
dc.identifier.issn | 0040-8727 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77635 | - |
dc.description.abstract | Hepatic fibrosis is characterized by excessive accumulation of extracellular matrix. Matrix metalloproteinases (MMPs) play an important role in the remodeling of the extracellular matrix during hepatic fibrosis. Lipocalin-2 (LCN2) forms complexes with MMP-9 and can be detected in the urine of patients with several types of cancers. The objective of this study was to examine the relationship between urinary LCN2 levels and MMP-9 activity with respect to the stage of liver fibrosis in patients with chronic hepatitis C (CHC), and to assess the utility of urine LCN2 as a non-invasive marker of hepatic fibrosis. Fresh spot urine samples were prospectively collected from forty-two interferon-naive CHC patients who underwent liver biopsy. The stage of hepatic fibrosis was assessed according to the METAVIR fibrosis score; 18 patients had no or mild fibrosis (stages F0 and F1) and 24 patients showed significant fibrosis (stages F2-F4). Immunoblot analyses demonstrated co-migration of urine LCN2 and MMP-9. Gelatin zymography showed that urinary MMP-9/MMP-2 activity ratios were higher in patients with significant fibrosis (F2-F4) than in patients no or mild fibrosis (F0-F1). Urine LCN2 levels which were normalized to urine creatinine concentration (urine LCN2-to-creatinine ratio; ULCR) were higher in F2-F4 patients compared to F0-F1 patients. There was a positive correlation between ULCR and urine MMP-9/MMP-2 activity ratios (r = 0.735). ULCR and AST-to-platelet ratio index were independent predictors of significant fibrosis by multivariate analysis. The present study suggests that urinary LCN2 is a novel marker of hepatic fibrosis by reflecting urine MMP-9 activity in CHC. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | TOHOKU UNIV MEDICAL PRESS | ko_KR |
dc.subject | fibrosis | ko_KR |
dc.subject | hepatitis C virus | ko_KR |
dc.subject | lipocalin-2 | ko_KR |
dc.subject | urine | ko_KR |
dc.subject | matrix metalloproteinase-9 | ko_KR |
dc.title | Increased Urinary Lipocalin-2 Reflects Matrix Metalloproteinase-9 Activity in Chronic Hepatitis C with Hepatic Fibrosis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김진욱 | - |
dc.contributor.AlternativeAuthor | 이상협 | - |
dc.contributor.AlternativeAuthor | 정숙향 | - |
dc.contributor.AlternativeAuthor | 김혜령 | - |
dc.contributor.AlternativeAuthor | 안근수 | - |
dc.contributor.AlternativeAuthor | 조재영 | - |
dc.contributor.AlternativeAuthor | 윤유석 | - |
dc.contributor.AlternativeAuthor | 한호승 | - |
dc.identifier.doi | 10.1620/tjem.222.319 | - |
dc.citation.journaltitle | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | - |
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dc.description.tc | 0 | - |
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