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Aging and Arterial Stiffness

Cited 336 time in Web of Science Cited 354 time in Scopus
Authors
Lee, Hae-Young; Oh, Byung-Hee
Issue Date
2010-11
Publisher
JAPANESE CIRCULATION SOC
Citation
CIRCULATION JOURNAL; Vol.74 11; 2257-2262
Keywords
AgingHypertensionStiffnessVasculature
Abstract
Arterial walls stiffen with age. The most consistent and well-reported changes are luminal enlargement with wall thickening and a reduction of elastic properties at the level of large elastic arteries. Longstanding arterial pulsation in the central artery causes elastin fiber fatigue and fracture. Increased vascular calcification and endothelial dysfunction are also characteristic of arterial aging. These changes lead to increased pulse wave velocity, especially along central elastic arteries, and increases in systolic blood pressure and pulse pressure. Vascualar aging is accelerated by coexsiting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Vascular aging is an independent risk factor for cardiovascular disease, from atherosclerosis to target organ damage, including coronary artery disease, stroke and heart failure. Various strategies, especially controlling hypertension, show benefit in preventing, delaying or attenuating vascular aging. (Circ J 2010; 74: 2257-2262)
ISSN
1346-9843
Language
English
URI
https://hdl.handle.net/10371/77641
DOI
https://doi.org/10.1253/circj.CJ-10-0910
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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