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Tumor Size and Age Predict the Risk of Malignancy in Hurthle Cell Neoplasm of the Thyroid and Can Therefore Guide the Extent of Initial Thyroid Surgery
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Hyuk | - |
dc.contributor.author | Lim, Jung Ah | - |
dc.contributor.author | Ahn, Hwa Young | - |
dc.contributor.author | Lee, Eun Kyung | - |
dc.contributor.author | Kim, Kyung Won | - |
dc.contributor.author | Park, Young Joo | - |
dc.contributor.author | Kim, Kwang Hyun | - |
dc.contributor.author | Cho, Bo Youn | - |
dc.contributor.author | Youn, Yeo Kyu | - |
dc.contributor.author | Park, Do Joon | - |
dc.contributor.author | Choi, Yun-Hee | - |
dc.contributor.author | Min, Hye Sook | - |
dc.date.accessioned | 2012-06-27T08:02:50Z | - |
dc.date.available | 2012-06-27T08:02:50Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | THYROID; Vol.20 11; 1229-1234 | ko_KR |
dc.identifier.issn | 1050-7256 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77646 | - |
dc.description.abstract | Background: The majority of patients having a diagnosis of Hurthle cell neoplasm (HCN) on fine-needle aspiration (FNA) of a thyroid nodule have a diagnostic thyroid lobectomy to make the final diagnosis. If the nodule is malignant, they require a completion thyroidectomy. The objective of this study was to devise a simple clinical scheme capable of predicting malignancy in patients with cytologic diagnosis of HCN and, therefore, guide the extent of initial thyroid surgery. Methods: A total of 57 patients who underwent thyroid surgery after an FNA diagnosis of HCN were retrospectively studied. The patients were examined for clinical features, preoperative imaging studies, and pathology reports. The risk of malignancy was calculated using a multiple logistic regression model. Results: The overall rate of malignancy in patients with HCN was 46% (26/57). The predictors of malignancy based on multiple logistic regression analysis were tumor size >1.5 cm (odds ratio [95% confidence interval] 8.0 [1.9-33.4]) and patient age >45 years (odds ratio [95% confidence interval] 2.3 [0.6-8.6]). In patients with nodules larger than 1.5 cm, the predicted probability of malignancy was greater in patients over 45 years than in younger patients (65% for >45 years vs. 44% for <= 45 years). In patients with a nodule 1.5 cm or less, the probability of malignancy was relatively low and not significantly different between the two age categories (18% for >45 years vs. 10% for <= 45 years). Conclusions: This study suggests that tumor size and age can be integrated into decision making for patients with an FNA diagnosis of HCN to facilitate patient selection for surgical referral and, particularly, to determine in which patients a thyroidectomy rather than a lobectomy should be the initial surgery. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | MARY ANN LIEBERT INC | ko_KR |
dc.title | Tumor Size and Age Predict the Risk of Malignancy in Hurthle Cell Neoplasm of the Thyroid and Can Therefore Guide the Extent of Initial Thyroid Surgery | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김태혁 | - |
dc.contributor.AlternativeAuthor | 임정아 | - |
dc.contributor.AlternativeAuthor | 안화영 | - |
dc.contributor.AlternativeAuthor | 이은경 | - |
dc.contributor.AlternativeAuthor | 민혜숙 | - |
dc.contributor.AlternativeAuthor | 김경원 | - |
dc.contributor.AlternativeAuthor | 최윤희 | - |
dc.contributor.AlternativeAuthor | 박영주 | - |
dc.contributor.AlternativeAuthor | 박도준 | - |
dc.contributor.AlternativeAuthor | 김광현 | - |
dc.contributor.AlternativeAuthor | 윤여규 | - |
dc.contributor.AlternativeAuthor | 조보연 | - |
dc.identifier.doi | 10.1089/thy.2009.0443 | - |
dc.citation.journaltitle | THYROID | - |
dc.description.citedreference | Montone KT, 2008, ARCH PATHOL LAB MED, V132, P1241 | - |
dc.description.citedreference | Moon WJ, 2008, RADIOLOGY, V247, P762, DOI 10.1148/radiol.2473070944 | - |
dc.description.citedreference | Sippel RS, 2008, WORLD J SURG, V32, P702, DOI 10.1007/s00268-007-9416-5 | - |
dc.description.citedreference | Wu HHJ, 2008, DIAGN CYTOPATHOL, V36, P149, DOI 10.1002/dc.20750 | - |
dc.description.citedreference | GRUBE E, 2007, INT J MED SCI, V4, P249 | - |
dc.description.citedreference | Pu RT, 2006, DIAGN CYTOPATHOL, V34, P330, DOI 10.1002/dc.20440 | - |
dc.description.citedreference | Elliott DD, 2006, CANCER CYTOPATHOL, V108, P102, DOI 10.1002/cncr.21716 | - |
dc.description.citedreference | Alaedeen DI, 2005, SURGERY, V138, P650, DOI 10.1016/j.surg.2005.06.047 | - |
dc.description.citedreference | Schisterman EF, 2005, EPIDEMIOLOGY, V16, P73, DOI 10.1097/01.ede.0000147512.81966.ba | - |
dc.description.citedreference | Giorgadze T, 2004, DIAGN CYTOPATHOL, V31, P307, DOI 10.1002/dc.20132 | - |
dc.description.citedreference | Pisanu A, 2004, WORLD J SURG, V28, P761, DOI 10.1007/s00268-004-7312-9 | - |
dc.description.citedreference | Obuchowski NA, 2003, RADIOLOGY, V229, P3, DOI 10.1148/radiol.2291010898 | - |
dc.description.citedreference | Lopez-Penabad L, 2003, CANCER, V97, P1186, DOI 10.1002/cncr.11176 | - |
dc.description.citedreference | YANG GC, 2003, ENDOCR PRACT, V9, P510 | - |
dc.description.citedreference | Renshaw AA, 2002, CANCER CYTOPATHOL, V96, P261, DOI 10.1002/cncr.10797 | - |
dc.description.citedreference | Hundahl SA, 2000, CANCER, V89, P202 | - |
dc.description.citedreference | McHenry CR, 1999, SURGERY, V126, P798 | - |
dc.description.citedreference | Baloch ZW, 1999, SEMIN DIAGN PATHOL, V16, P190 | - |
dc.description.citedreference | Tuttle RM, 1998, THYROID, V8, P377 | - |
dc.description.citedreference | Chen H, 1998, ANN SURG, V227, P542 | - |
dc.description.citedreference | Hosmer DW, 1997, STAT MED, V16, P965 | - |
dc.description.citedreference | Faraggi D, 1996, STAT MED, V15, P2203 | - |
dc.description.citedreference | APEL RL, 1995, AM J SURG PATHOL, V19, P810 | - |
dc.description.citedreference | ONGPHIPHADHANAKUL B, 1992, ACTA ENDOCRINOL-COP, V126, P233 | - |
dc.description.citedreference | MCLEOD MK, 1990, OTOLARYNG CLIN N AM, V23, P441 | - |
dc.description.citedreference | LIVOLSI V, 1990, SURG PATHOLOGY THYRO | - |
dc.description.citedreference | HEDINGER C, 1988, HISTOLOGIC TYPING TH | - |
dc.description.citedreference | ARGANINI M, 1986, SURGERY, V100, P1108 | - |
dc.description.citedreference | WATSON RG, 1984, MAYO CLIN PROC, V59, P851 | - |
dc.description.tc | 0 | - |
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