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Three phenotypes of obstructive lung disease in the elderly

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dc.contributor.authorJo, K-W.-
dc.contributor.authorRa, S. W.-
dc.contributor.authorChae, E. J.-
dc.contributor.authorSeo, J. B.-
dc.contributor.authorLee, J-H.-
dc.contributor.authorLee, Y. K.-
dc.contributor.authorHuh, J. W.-
dc.contributor.authorLee, J. H.-
dc.contributor.authorLim, S. Y.-
dc.contributor.authorOh, Y-M.-
dc.contributor.authorLee, S-D.-
dc.contributor.authorLee, J. S.-
dc.contributor.authorSheen, S. S.-
dc.contributor.authorYoon, H. I.-
dc.contributor.authorShin, T. R.-
dc.contributor.authorLee, S-M.-
dc.contributor.authorKim, W. J.-
dc.contributor.authorKim, T-H.-
dc.contributor.authorKim, E-K.-
dc.contributor.authorKim, N. K.-
dc.date.accessioned2012-06-27T08:35:36Z-
dc.date.available2012-06-27T08:35:36Z-
dc.date.issued2010-11-
dc.identifier.citationINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE; Vol.14 11; 1481-1488ko_KR
dc.identifier.issn1027-3719-
dc.identifier.urihttps://hdl.handle.net/10371/77652-
dc.description.abstractSETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To classify the phenotypes in elderly subjects with obstructive lung disease (OLD). METHODS: We analysed 191 subjects aged >= 60 years with chronic respiratory symptoms and either obstructive spirometry or bronchial hyperresponsiveness. Factor analysis was performed using commonly measured variables and revealed four significant variables: 1) the ratio of inspiratory capacity to total lung capacity, 2) the total score on the St George`s Respiratory Questionnaire, 3) the volume fraction of the lung less than 950 Hounsfield Unit at full inspiration on volumetric computed tomography and 4) post-bronchodilator forced expiratory volume in 1 second (FEV(1)) changes. We performed a cluster analysis on these four variables. RESULTS: The mean age was 68.5 (+/- 5.2 SD) years and the mean post-bronchodilator FEV(1) was 52.4% (+/- 16.5) predicted. Three clusters with the following phenotypes were identified: Cluster 1 included subjects with moderate to severe airflow obstruction and bronchodilator reversibility; Cluster 2 subjects had moderate airflow obstruction without bronchodilator reversibility, and Cluster 3 subjects had severe airflow obstruction without bronchodilator reversibility. CONCLUSIONS: We identified three phenotypes in elderly subjects with OLD. Follow-up studies are needed to explore the clinical significance of each phenotype.ko_KR
dc.description.sponsorshipThis study was supported by grants from the Korea Healthcare
Technology R&D Project, Ministry for Health, Welfare and Family
Affairs, Republic of Korea (A040153) and the Asan Institute for
Life Science, Seoul, Korea (05-306).
ko_KR
dc.language.isoenko_KR
dc.publisherINT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)ko_KR
dc.subjectchronic bronchitisko_KR
dc.subjectemphysemako_KR
dc.subjectasthmako_KR
dc.subjectelderlyko_KR
dc.subjectobstructive lung diseaseko_KR
dc.titleThree phenotypes of obstructive lung disease in the elderlyko_KR
dc.typeArticleko_KR
dc.citation.journaltitleINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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