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The Biological Monitoring of Urinary 1-hydroxypyrene by PAH Exposure Among Smokers
DC Field | Value | Language |
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dc.contributor.author | Lee, K. H. | - |
dc.contributor.author | Byeon, S. H. | - |
dc.date.accessioned | 2012-06-28T00:07:18Z | - |
dc.date.available | 2012-06-28T00:07:18Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH; Vol.4 3; 439-442 | ko_KR |
dc.identifier.issn | 1735-6865 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77664 | - |
dc.description.abstract | This study examines changes in the urinary 1-hydroxypyrene (1-OHP) concentration as a polycyclic aromatic hydrocarbon (PAH) metabolite related to smoking among eight volunteers. The study subjects consisted of 8 participants (2 smokers, 4 ex-smokers and 2 non-smokers; mean age 23, range 21 24 years old) in a smoking cessation program. Three urine samples were collected each week for 4 weeks from each participant to give a total of 96 urine samples. None of the participants smoked during the study period. Levels of urinary 1-OHP, as an internal dose marker of smoke containing PAHs, were measured by high performance liquid chromatography (HPLC) fluorescence detector. Urinary 1-OHP levels in the ex-smokers were decreased during the 4 weeks study period, due to ambient sources of PAH exposure. Thus, smoking cessation was only expected to result in reduction of urinary 1-OHP. Urinary 1-OHP levels were significantly correlated with the amounts of cigarettes smoked, as assessed by the questionnaire (Spearman`s correlation coefficient, r=0.23, P=0.03). This study suggested that urinary 1-OHP can be a potentially useful biomarker of smoke. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | UNIV TEHRAN | ko_KR |
dc.subject | Biomarker | ko_KR |
dc.subject | 1-hydroxypyrene | ko_KR |
dc.subject | Cigarette smoking | ko_KR |
dc.subject | Polycyclic aromatic hydrocarbons | ko_KR |
dc.title | The Biological Monitoring of Urinary 1-hydroxypyrene by PAH Exposure Among Smokers | ko_KR |
dc.type | Article | ko_KR |
dc.citation.journaltitle | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH | - |
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dc.description.tc | 2 | - |
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